Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0343480
Funding Status
Closed
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Funded Activity Summary
Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. Using the combined expertise of the applicants, it is proposed to stereospecifically synthesise dinuclear complexes and study their DNA binding. This will greatly assist in the development of drugs that can selectively target genes and altered DNA.Funded Activity Details
Start Date: 2003
End Date: 12-2005
Funding Scheme: Discovery Projects
Funding Amount: $300,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Bioinorganic Chemistry | Inorganic Chemistry | Transition Metal Chemistry |
