Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0450405
Funding Status
Closed
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Funded Activity Summary
The control of elongation factor 2 and its role in the regulation of protein synthesis. Protein synthesis is a key process in living cells. The main stage, elongation, is regulated through phosphorylation of elongation factor eEF2 in response to hormones, amino acids and cellular energy status, via changes in the activity of eEF2 kinase. We will study how these conditions control eEF2 kinase by studying its phosphorylation and identifying new kinases that regulate it. We will explore the role of eEF2 in controlling protein synthesis, seek new substrates for eEF2 kinase and initiate work to elucidate the structure of this unusual enzyme. This will enhance, in a range of ways, fundamental understanding of cell physiology.Funded Activity Details
Start Date: 2004
End Date: 12-2008
Funding Scheme: Discovery Projects
Funding Amount: $570,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Enzymes | Biochemistry and Cell Biology | Cell Metabolism | Protein Targeting And Signal Transduction
ANZSRC Socio-Economic Objective (SEO)
Nutrition | Treatments (e.g. chemicals, antibiotics) | Cancer and related disorders |
