Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP200102291
Funding Status
Active
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Funded Activity Summary
Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Funded Activity Details
Start Date: 07-2020
End Date: 12-2024
Funding Scheme: Discovery Projects
Funding Amount: $450,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Genome Structure and Regulation | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Analytical Spectrometry |
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Infectious Diseases
