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Creatine Supplementation In Pregnancy: Utilising Cells’ “Built-In” Energy Buffering System
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Through pregnancy, the placenta transfers oxygen and nutrients from the mother to the baby. When a placenta doesn’t function properly a baby’s health is compromised. This can lead to morbidity or death. Creatine is the “back-up generator” of all cells and could help the failing placenta increase nutrient and oxygen delivery to the baby. This study will develop creatine as a potential new therapeutic, to improve the survival of babies of complicated pregnancies.
Asthma Management In Pregnancy: Evaluating Costs, Benefits And Behaviours
Funder
National Health and Medical Research Council
Funding Amount
$319,157.00
Summary
Asthma is the most common complication to affect pregnancy and it worsens with pregnancy contributing to an increased incidence of morbidity and mortality for the baby. We think we can improve the health of the pregnant, asthmatic mothers and prevent a poor outcome for the baby by empowering asthmatic mothers to self manage their disease through education in an antenatal setting. We will assess whether antenatal asthma education and management is a cost effective approach to managing this diseas ....Asthma is the most common complication to affect pregnancy and it worsens with pregnancy contributing to an increased incidence of morbidity and mortality for the baby. We think we can improve the health of the pregnant, asthmatic mothers and prevent a poor outcome for the baby by empowering asthmatic mothers to self manage their disease through education in an antenatal setting. We will assess whether antenatal asthma education and management is a cost effective approach to managing this disease during pregnancy.Read moreRead less
Healing Pressure Ulcers: Efficacy And Cost Effectiveness Of Nutrition Interventions In The Treatment Of Pressure Ulcers And Chronic Wounds
Funder
National Health and Medical Research Council
Funding Amount
$153,975.00
Summary
It makes sense that good nutrition should help with healing of pressure ulcers, yet there is little evidence of what type of diet or nutritional supplements, if any, can assist in pressure ulcer healing. This research program will investigate the value of different types of diets and nutritional supplements in the healing of pressure ulcers, in comparison with other forms of treatment and whether this is a cost effective approach.
New Approaches For Predicting Obstetric Complications: Measuring Circulating RNA Of Feto-placental Origin
Funder
National Health and Medical Research Council
Funding Amount
$322,286.00
Summary
Preeclampsia (PE) and intrauterine growth restriction are serious complications of pregnancy and are the leading causes of newborn death and disability. We propose developing a blood test to accurately predict those at high risk of these complications. Early prediction would provide clinicians an opportunity to intensively manage such pregnancies, enabling early intervention and maximising good outcomes.
Investigating The Antimicrobial Activity Of Zinc At The Host-pneumococcal Interface
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Streptococcus pneumoniae is a human-only bacterium that is responsible for killing more than one million people every year. This project will analyse how the human immune system fights this bacterium, and subsequently, how the bacteria manages to subvert these attacks and survive in the human host. This will provide crucial information for developing new drugs against this pathogen, in an attempt to combat the ever-increasing problem of antibiotic resistance.
Investigation And Therapeutic Targeting Of The Immune Mechanisms That Predispose To And Increase The Severity Of Influenza In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$326,097.00
Summary
In pregnancy there is suppression of maternal immunity to enable fetal implantation and growth. Respiratory viruses, like influenza, take advantage of these changes and cause infections that are more severe in pregnant women, affecting them and their babies. In this project we aim to identify specific immune responses against viruses that are reduced in pregnancy that can be selectively boosted. This has the potential to protect against viruses without affecting the pregnancy or baby.