Stronger, coarser-grained biodegradable zinc alloys. This project aims to develop stronger and more durable zinc alloys for a new generation of biodegradable metals for potential load-bearing orthopaedic applications. It expects to deliver a group of novel zinc alloys with better properties and a new technology for manufacturing them, and to use advanced experimental techniques to reveal deformation and strengthening mechanisms that underlie the unusual Hall-Petch and anomalous twinning phenomen ....Stronger, coarser-grained biodegradable zinc alloys. This project aims to develop stronger and more durable zinc alloys for a new generation of biodegradable metals for potential load-bearing orthopaedic applications. It expects to deliver a group of novel zinc alloys with better properties and a new technology for manufacturing them, and to use advanced experimental techniques to reveal deformation and strengthening mechanisms that underlie the unusual Hall-Petch and anomalous twinning phenomena and the unprecedented properties of these alloys. Expected outcomes are likely to form the technology and scientific basis for developing better biodegradable metallic alloys. This has the potential eventually to create a better life for thousands of Australian patients.Read moreRead less
Stronger zinc alloys for more flexible biodegradable stents. This project aims to develop stronger zinc alloys for a new class of biodegradable metallic stents. A key challenge for biodegradable stent technology is to make stents as thin as possible while also being strong. This project will develop ultra-high strength zinc alloys that can be used to fabricate thinner biodegradable stents for easier surgical operation. The project outcomes should be a major step in the design and development of ....Stronger zinc alloys for more flexible biodegradable stents. This project aims to develop stronger zinc alloys for a new class of biodegradable metallic stents. A key challenge for biodegradable stent technology is to make stents as thin as possible while also being strong. This project will develop ultra-high strength zinc alloys that can be used to fabricate thinner biodegradable stents for easier surgical operation. The project outcomes should be a major step in the design and development of a new generation of biodegradable stents that will avoid the risks associated with existing products and potentially create a better life for millions of patients worldwide.Read moreRead less
Innovative Zn alloys with essential mechanical and biofunctional properties. This project aims to develop a breakthrough understanding of the impact of alloying additions on the strengthening mechanisms, degradation behaviour, antibacterial properties and biofunctionalities of zinc alloys. The project expects to generate new knowledge in alloying strategies, plastic deformation and surface modification of zinc alloys to achieve mechanical, corrosion and biofunctional properties satisfying the re ....Innovative Zn alloys with essential mechanical and biofunctional properties. This project aims to develop a breakthrough understanding of the impact of alloying additions on the strengthening mechanisms, degradation behaviour, antibacterial properties and biofunctionalities of zinc alloys. The project expects to generate new knowledge in alloying strategies, plastic deformation and surface modification of zinc alloys to achieve mechanical, corrosion and biofunctional properties satisfying the requirements of biodegradable metallic materials. The expected outcomes are the development of novel zinc alloys and practical technologies for industry applications, such as thermomechanical processing and surface coating. The benefits are expected to extend to physical metallurgy and biomaterial manufacturing.Read moreRead less
Oxygenation history of the Earth and the evolution of complex life. This project will investigate how and when the atmosphere became oxygen-rich by analyzing ancient barrier reefs and other rocks that formed between 1000 to 300 million years ago, spanning the appearance and diversification of animals and plants. The project is significant because the buildup of oxygen in the atmosphere was arguably the most important chemical process ever to have occurred on Earth and controlled the evolution of ....Oxygenation history of the Earth and the evolution of complex life. This project will investigate how and when the atmosphere became oxygen-rich by analyzing ancient barrier reefs and other rocks that formed between 1000 to 300 million years ago, spanning the appearance and diversification of animals and plants. The project is significant because the buildup of oxygen in the atmosphere was arguably the most important chemical process ever to have occurred on Earth and controlled the evolution of environments, climate and life. A major outcome will be an improved understanding of how the Earth's atmosphere and climate are regulated by geological processes. This project will generate new knowledge about how sedimentary zinc, lead and copper ore deposits form, which may guide exploration for these commodities.Read moreRead less
Thioamide ligations: new technologies for peptide and protein synthesis. This project aims to develop novel amide-bond forming reactions for the chemical synthesis of peptides and proteins. New peptide ligation strategies, including an asparagine-based ligation and a residue-independent ligation will be developed that exploit the recent discovery of silver-promoted coupling reactions of thioamides. A novel late-stage, chemo-selective assembly of N-glycosylated asparagine residues in peptides and ....Thioamide ligations: new technologies for peptide and protein synthesis. This project aims to develop novel amide-bond forming reactions for the chemical synthesis of peptides and proteins. New peptide ligation strategies, including an asparagine-based ligation and a residue-independent ligation will be developed that exploit the recent discovery of silver-promoted coupling reactions of thioamides. A novel late-stage, chemo-selective assembly of N-glycosylated asparagine residues in peptides and proteins will also be developed. The outcomes of this research will lead to breakthroughs in synthetic methodologies for the assembly and functionalisation of peptides and proteins, thereby enabling access to a range of homogeneous, post translationally modified proteins though total chemical synthesis. These research outcomes will expand Australia's research capability and global competitiveness in the field of biotechnology, delivering significant benefits to the third largest manufacturing sector in Australia.Read moreRead less
Boosting C4 photosynthesis to climate proof crop yields. Building next generation C4 crops, such as maize, sugarcane and sorghum, to cope with drought and heat stress is requisite to ensure the supply of food and fodder. Here we will increase the content and / or catalytic efficiency of the primary carboxylase of C4 photosynthesis (PEPC) that supplies CO2 to the carbon concentrating mechanism and ensures high photosynthetic rates. We will develop new SynBio tools to create and test novel PEPC is ....Boosting C4 photosynthesis to climate proof crop yields. Building next generation C4 crops, such as maize, sugarcane and sorghum, to cope with drought and heat stress is requisite to ensure the supply of food and fodder. Here we will increase the content and / or catalytic efficiency of the primary carboxylase of C4 photosynthesis (PEPC) that supplies CO2 to the carbon concentrating mechanism and ensures high photosynthetic rates. We will develop new SynBio tools to create and test novel PEPC isoforms with desirable properties. Ultimately, the project aims to identify isoforms that improve plant fitness under stress conditions. Optimising PEPC activity will provide next generation solutions to improve water balance and carbon assimilation to keep C4 crops productive under future climates.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100027
Funder
Australian Research Council
Funding Amount
$4,340,802.00
Summary
ARC Training Centre for Biopharmaceutical Innovation. ARC Training Centre for Biopharmaceutical Innovation. This centre aims to transform Australia’s growing biopharmaceutical industry, an advanced manufacturing capability, by training specialist biotechnologists and bioengineers. It expects the research and development outputs will create new biopharmaceuticals and antibody-based reagents, enhanced production methods, improved manufacturing capabilities and a cohort of specialist scientists. Ne ....ARC Training Centre for Biopharmaceutical Innovation. ARC Training Centre for Biopharmaceutical Innovation. This centre aims to transform Australia’s growing biopharmaceutical industry, an advanced manufacturing capability, by training specialist biotechnologists and bioengineers. It expects the research and development outputs will create new biopharmaceuticals and antibody-based reagents, enhanced production methods, improved manufacturing capabilities and a cohort of specialist scientists. New biopharmaceuticals are expected to benefit the Australian economy and provide new therapeutic options for better health outcomes. Industry-driven research projects will also provide industry-ready graduates who can drive future growth in the sector.Read moreRead less
Novel green scalable chemical peptide synthesis and enzyme immobilization. The Project aims to address the critical issue of developing green processes for the chemical production of peptides including on an industrial scale. It will use unique, biocompatible solid supports that have been invented by our partner SpheriTech Ltd together with other reagents to allow synthesis to be conducted in water rather than toxic organic solvents. Expected outcomes of the Project include an international part ....Novel green scalable chemical peptide synthesis and enzyme immobilization. The Project aims to address the critical issue of developing green processes for the chemical production of peptides including on an industrial scale. It will use unique, biocompatible solid supports that have been invented by our partner SpheriTech Ltd together with other reagents to allow synthesis to be conducted in water rather than toxic organic solvents. Expected outcomes of the Project include an international partnership in highly efficient environmentally-friendly assembly of peptides and of their analogues by both solid phase synthesis and immobilized enzyme-mediated ligation. The clear benefit will be the first novel, water-based, scalable green synthesis of peptides as biological probes and potential therapeutic agents.Read moreRead less
Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an i ....Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an initial screen, distinct variants and combinations of these genes were identified. This project aims to interrogate how variation in these critical genes impacts on the function of cytotoxic lymphocytes, providing insights into the evolutionary drivers of immune recognition mechanisms.Read moreRead less