The Role Of Presenilin In Metal Homeostasis And Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$86,335.00
Summary
Presenilin, a protein involved in Alzheimer’s disease (AD), may regulate copper and zinc levels. Copper and zinc are essential nutrients however a deficiency or excess can cause disease. Promising metal-altering AD drugs, are in various stages of clinical trial. I aim to characterize the interaction of Presenilin and metals using both mouse and cultured human cell models that are deficient in Presenilin. Understanding this interaction should lead to better drug design and treatment of AD.
Investigating The Antimicrobial Activity Of Zinc At The Host-pneumococcal Interface
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Streptococcus pneumoniae is a human-only bacterium that is responsible for killing more than one million people every year. This project will analyse how the human immune system fights this bacterium, and subsequently, how the bacteria manages to subvert these attacks and survive in the human host. This will provide crucial information for developing new drugs against this pathogen, in an attempt to combat the ever-increasing problem of antibiotic resistance.
The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and ....The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and legislative motivation for reducing fuel emissions, the development of new Mg-based alloys capable of meeting this demand from automotive manufacturers represents both a potentially large economic advantage to the country of development as well as helping to address the environmental concern about fuel emissions.Read moreRead less
The early tectonic evolution of the Curnamona Province. This project aims to test the hypothesis that the Curnamona Province preserves evidence for an extension-related structural geology architecture. This will allow a comparison of the basin evolution, crustal architecture and mechanisms of basin development between the Curnamona Province and well-understood basins of the Mount Isa Inlier. The project is expected to add value to pre-existing databases, and deliver a plate tectonic and str ....The early tectonic evolution of the Curnamona Province. This project aims to test the hypothesis that the Curnamona Province preserves evidence for an extension-related structural geology architecture. This will allow a comparison of the basin evolution, crustal architecture and mechanisms of basin development between the Curnamona Province and well-understood basins of the Mount Isa Inlier. The project is expected to add value to pre-existing databases, and deliver a plate tectonic and structural framework to interpret basin evolution and constrain geochronology/geochemical analysis, and develop a three-dimesional crustal architecture. The results will provide new constraints on the evolution of the Australian plate, and how the Australian crust has evolved.Read moreRead less
Improving the Continuous Copper Converting Process Using Ferrous Calcium Silicate Slags. Replacement of refractories due to slag attack is a major cost in the copper making process. Metallurgists need to find a better slag which retains the benefits of current slags but is less aggressive towards refractories. This project will assess the suitability of a newly proposed ferrous calcium silicate slag for continuous copper converting. The outcomes will be to: (1) provide fundamental knowledge of ....Improving the Continuous Copper Converting Process Using Ferrous Calcium Silicate Slags. Replacement of refractories due to slag attack is a major cost in the copper making process. Metallurgists need to find a better slag which retains the benefits of current slags but is less aggressive towards refractories. This project will assess the suitability of a newly proposed ferrous calcium silicate slag for continuous copper converting. The outcomes will be to: (1) provide fundamental knowledge of the properties of the SiO2-CaO-FeO slag system, (2) provide data on the rate and mechanism of refractory attack by this slag and (3) enable the copper smelting industry to assess the potential of this slag to reduce operating costs.Read moreRead less
Unearthing the Marginal Terranes of the South Australian Craton: Keystone of Proterozoic Australia. This project will investigate the buried geology of vast regions of northern South Australia that is likely to be compatible with rocks that host enormous mineral wealth including the giant Broken Hill and Olympic Dam deposits. We will access these buried rocks using a program of on-shore scientific drilling that will provide the ground truth for multi-million dollar federal and state government ....Unearthing the Marginal Terranes of the South Australian Craton: Keystone of Proterozoic Australia. This project will investigate the buried geology of vast regions of northern South Australia that is likely to be compatible with rocks that host enormous mineral wealth including the giant Broken Hill and Olympic Dam deposits. We will access these buried rocks using a program of on-shore scientific drilling that will provide the ground truth for multi-million dollar federal and state government funded geophysical data acquisition. Results will help identify prospective mineral belts and determine the processes responsible for their formation.Read moreRead less
Platinum deposit genesis: A new way of thinking. Platinum is becoming increasingly crucial to the high technology sector, and is used particularly in catalytic converters and fuel cells, which serve to minimise or eliminate car exhaust pollution. Greatly expanded resources of this precious metal are needed to help society's transition to a low carbon dioxide (CO2) lifestyle. This project will combine high temperature-pressure experiments with geological field research to greatly improve our unde ....Platinum deposit genesis: A new way of thinking. Platinum is becoming increasingly crucial to the high technology sector, and is used particularly in catalytic converters and fuel cells, which serve to minimise or eliminate car exhaust pollution. Greatly expanded resources of this precious metal are needed to help society's transition to a low carbon dioxide (CO2) lifestyle. This project will combine high temperature-pressure experiments with geological field research to greatly improve our understanding of how platinum ore deposits form and thus where to find them. The outcomes of this project will change mineral exploration strategies in Australia and around the world, and facilitate our progression to a cleaner, greener future.Read moreRead less
Evolution of the Proterozoic lithosphere and its bearing of sediment hosted base metal mineralisation. This project aims to determine the aspects of lithospheric evolution that led to a concentration of giant base metal mineral deposits in the Early to Middle Proterozoic (ca 1.9-1.5 billion years ago). We propose to test three related hypotheses that, if validated, will fundamentally change our view of Proterozoic metallogenesis and the way the mineral industry approaches exploration for these ....Evolution of the Proterozoic lithosphere and its bearing of sediment hosted base metal mineralisation. This project aims to determine the aspects of lithospheric evolution that led to a concentration of giant base metal mineral deposits in the Early to Middle Proterozoic (ca 1.9-1.5 billion years ago). We propose to test three related hypotheses that, if validated, will fundamentally change our view of Proterozoic metallogenesis and the way the mineral industry approaches exploration for these deposits.Read moreRead less
Stronger, coarser-grained biodegradable zinc alloys. This project aims to develop stronger and more durable zinc alloys for a new generation of biodegradable metals for potential load-bearing orthopaedic applications. It expects to deliver a group of novel zinc alloys with better properties and a new technology for manufacturing them, and to use advanced experimental techniques to reveal deformation and strengthening mechanisms that underlie the unusual Hall-Petch and anomalous twinning phenomen ....Stronger, coarser-grained biodegradable zinc alloys. This project aims to develop stronger and more durable zinc alloys for a new generation of biodegradable metals for potential load-bearing orthopaedic applications. It expects to deliver a group of novel zinc alloys with better properties and a new technology for manufacturing them, and to use advanced experimental techniques to reveal deformation and strengthening mechanisms that underlie the unusual Hall-Petch and anomalous twinning phenomena and the unprecedented properties of these alloys. Expected outcomes are likely to form the technology and scientific basis for developing better biodegradable metallic alloys. This has the potential eventually to create a better life for thousands of Australian patients.Read moreRead less
Stronger zinc alloys for more flexible biodegradable stents. This project aims to develop stronger zinc alloys for a new class of biodegradable metallic stents. A key challenge for biodegradable stent technology is to make stents as thin as possible while also being strong. This project will develop ultra-high strength zinc alloys that can be used to fabricate thinner biodegradable stents for easier surgical operation. The project outcomes should be a major step in the design and development of ....Stronger zinc alloys for more flexible biodegradable stents. This project aims to develop stronger zinc alloys for a new class of biodegradable metallic stents. A key challenge for biodegradable stent technology is to make stents as thin as possible while also being strong. This project will develop ultra-high strength zinc alloys that can be used to fabricate thinner biodegradable stents for easier surgical operation. The project outcomes should be a major step in the design and development of a new generation of biodegradable stents that will avoid the risks associated with existing products and potentially create a better life for millions of patients worldwide.Read moreRead less