A Randomised Clinical Trial Of Internet-based Treatment For Binge Drinking And Depression In Young Australians
Funder
National Health and Medical Research Council
Funding Amount
$941,787.00
Summary
This project focuses on a common clinical problem that causes substantial functional, economic and health impacts; comorbid depression and binge drinking. These conditions are under-treated and peak in young adulthood. This project offers a low cost, wide reach, youth-appropriate treatment, which will have profound implications for service design and health policy. It relates to current Commonwealth initiatives in e-health and e-Psychology.
Gene - Environment Interactions As Predictors Of Clinical Outcome In At Risk Mental State
Funder
National Health and Medical Research Council
Funding Amount
$1,033,620.00
Summary
The grant aims to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia. Translation to clinical practice will be facilitated by experimental and risk assessment bioinformatics research. This will enable the (i) identification of modifiable biological and cognitive mechanisms and (ii) construction of tools which can be used for the early prediction of transition to psychotic disorder and outcome monitoring. Th ....The grant aims to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia. Translation to clinical practice will be facilitated by experimental and risk assessment bioinformatics research. This will enable the (i) identification of modifiable biological and cognitive mechanisms and (ii) construction of tools which can be used for the early prediction of transition to psychotic disorder and outcome monitoring. This study will identify the factors that translate genetic vulnerability to schizophrenia into overt illness. The key risk factors of stress and substance use and other environmental features will be studied as part of randomised clinical trials in young people with early symptoms who are at immediate risk of schizophrenia. This study forms part of a much larger international program of research focusing on clarifying how the vulnerability to schizophrenia develops and how it can ultimately be preventedRead moreRead less
PRE-EMPT: Prediction Of Early Mental Disorder And Preventive Treatment - Centre Of Research Excellence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
Mental health clinicians currently do not have the means to predict which young people with emerging symptoms are most at risk of progressing to serious mental illness. This CRE will help us better understand how mental illnesses develop, identify the risk and protective factors, and introduce tools for use in clinical practice to better predict onset of serious mental illness. This will help with providing and further developing early treatments to delay or prevent the onset of mental illness.
A Large-scale Clinical Effectiveness (health Services) Trial To Determine Whether Personalised Health Care Packages, Combined With Digitally-supported Measurement-based Care, Improve Functional Outcomes In Young People With Mood Disorders
Funder
National Health and Medical Research Council
Funding Amount
$3,434,588.00
Summary
One of our greatest current health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders. This research will combine our national expertise to develop and implement care packages utilising digital technologies, personalised assessment techniques, targeted treatment choices, and long-term outcome tracking. In a clinical trial we will assess the clinical effectiveness of these innovative healthcare packages.
Reducing The Injury And Disease Burden Attributable To Alcohol: Methodological, Aetiological And Intervention Studies.
Funder
National Health and Medical Research Council
Funding Amount
$408,412.00
Summary
The research examines the influence of individual, social and environmental factors on drinking behaviour, and seeks to determine the effectiveness of strategies to prevent alcohol-related harm, with a particular focus on youth drinking. A series of studies is proposed, examining the validity of methods for measuring drinking behaviour; social and environmental factors, and interventions. The findings will have relevance to reducing the burden of alcohol-related injury and disease in Australia.
Antipsychotic Medication In First-episode Psychosis: An RCT To Assess The Risk-benefit Ratio
Funder
National Health and Medical Research Council
Funding Amount
$1,141,117.00
Summary
There has been an increasing emphasis on intervening early in psychotic disorders. A fundamental principle in early intervention is “to do no harm” and benefits must outweigh the risks of treatment. While antipsychotic medication is very effective and evidence-based form of treatment for positive symptoms in most first episode psychosis (FEP) patients it has risks. This study has the potential to determine whether antipsychotic medication should be the initial treatment option for FEP.
First-Line Management Of Youth Depression: A Randomised Placebo-Controlled Trial Of Fluoxetine And Cognitive Behavioural Therapy
Funder
National Health and Medical Research Council
Funding Amount
$1,316,648.00
Summary
The study aims to establish how to best treat adolescents and young adults when they present to mental health clinics with moderate-to-severe depression. There is, at present, considerable uncertainty as to whether young people should be started on antidepressant treatment at the same time as psychotherapy, or whether psychotherapy alone be commenced first. The study aims to clarify this important issue by implementing a trial that compares both treatment approaches.
Neuroimaging In Mental Health: The Quest For Clinically Useful Biomarkers
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
To ultimately improve treatment of mental illness, this research program aims to detect robust and reliable neuroimaging markers that are associated with affective disorders by pooling data from many samples across the world. Moreover, this research aims to develop alternative biological-based classifications of mental illness in young people, and evaluate their clinical value by examining their predictive value for treatment response and disease course.
Preventing Suicide In Young People: A Public Health Approach
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Suicide is the leading cause of death in young Australians. This fellowship aims to lower risk for suicide by testing: a) whether improving the connectedness of adolescents in schools can improve help-seeking, b) whether parents can learn to recognise risk in their children, and c) whether school screening is an appropriate and effective strategy to reduce risk. Practical outcomes will be new programs for youth, new strategies for parents and a better integrated approach for Australian schools.
Discovery Early Career Researcher Award - Grant ID: DE240100066
Funder
Australian Research Council
Funding Amount
$445,017.00
Summary
Contemporary social and environmental risks for youth offending. While social and technology changes have led to reductions in low-level youth offending, chronic youth offending has not reduced notably, and is growing in areas of Australia. This project aims to generate new knowledge on underlying social and environmental risks for chronic youth offending in Australia to improve the effectiveness of crime prevention and desistance strategies to reduce reoffending. This project uses longitudinal ....Contemporary social and environmental risks for youth offending. While social and technology changes have led to reductions in low-level youth offending, chronic youth offending has not reduced notably, and is growing in areas of Australia. This project aims to generate new knowledge on underlying social and environmental risks for chronic youth offending in Australia to improve the effectiveness of crime prevention and desistance strategies to reduce reoffending. This project uses longitudinal survey and youth justice data, and interviews with young people, to identify key social and environmental risks for chronic youth offending. Expected outcomes of the project include evidence to inform effective crime prevention and desistance strategies for young people ‘at risk’ or engaged in chronic offending.Read moreRead less