Gene - Environment Interactions As Predictors Of Clinical Outcome In At Risk Mental State
Funder
National Health and Medical Research Council
Funding Amount
$1,033,620.00
Summary
The grant aims to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia. Translation to clinical practice will be facilitated by experimental and risk assessment bioinformatics research. This will enable the (i) identification of modifiable biological and cognitive mechanisms and (ii) construction of tools which can be used for the early prediction of transition to psychotic disorder and outcome monitoring. Th ....The grant aims to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia. Translation to clinical practice will be facilitated by experimental and risk assessment bioinformatics research. This will enable the (i) identification of modifiable biological and cognitive mechanisms and (ii) construction of tools which can be used for the early prediction of transition to psychotic disorder and outcome monitoring. This study will identify the factors that translate genetic vulnerability to schizophrenia into overt illness. The key risk factors of stress and substance use and other environmental features will be studied as part of randomised clinical trials in young people with early symptoms who are at immediate risk of schizophrenia. This study forms part of a much larger international program of research focusing on clarifying how the vulnerability to schizophrenia develops and how it can ultimately be preventedRead moreRead less
Enhancing Mental Health In Aboriginal People: Reducing Violence And Developing Resilience
Funder
National Health and Medical Research Council
Funding Amount
$1,771,151.00
Summary
This project aims to determine the best ways to improve the Social Emotional Well Being (SEWB) of the Aboriginal people of Broken Hill, Menindee and Wilcannia. This project will develop a culturally appropriate and evidenced based intervention to break the cycle of ongoing grief, mental illness, alcohol and other drugs and violence. The project will proceed in a number of interrelated phases including extensive community consultations and a baseline survey. The project will then implement and ev ....This project aims to determine the best ways to improve the Social Emotional Well Being (SEWB) of the Aboriginal people of Broken Hill, Menindee and Wilcannia. This project will develop a culturally appropriate and evidenced based intervention to break the cycle of ongoing grief, mental illness, alcohol and other drugs and violence. The project will proceed in a number of interrelated phases including extensive community consultations and a baseline survey. The project will then implement and evaluate an intervention program that provides a community and individual program that adopts evidence-based approaches and modifies them to be acceptable within Aboriginal communities. These interventions aim to break the cycle of violence and mental health problems by teaching adaptive skills to reduce violent behaviours and by providing mental health interventions that reduce disorders that contribute to violence.Read moreRead less