The development of particle-depleted regions in dense suspensions of neutrally buoyant particles. We aim to measure the spatial variation of fluid speed and particle speed, and of particle concentration, across and along a pipe into which has been introduced a mixture of said particles and fluid. This problem has significance in mechanical and chemical engineering wherever particle/fluid mixtures are flowing. The expected outcomes are recognition of a major contribution to world research, as w ....The development of particle-depleted regions in dense suspensions of neutrally buoyant particles. We aim to measure the spatial variation of fluid speed and particle speed, and of particle concentration, across and along a pipe into which has been introduced a mixture of said particles and fluid. This problem has significance in mechanical and chemical engineering wherever particle/fluid mixtures are flowing. The expected outcomes are recognition of a major contribution to world research, as well as technological applications; one that motivates us is the blood shear in the bearings of a revolutionary Australian blood pump for cardiac assist that avoids both pivots and magnetic suspension for the single moving part.Read moreRead less
Tissue Engineering of Human Heart Valve Grown In Vitro. Tissue engineering (TE) of heart valves is a new approach to cultivate a functional heart valve from human autologous cells. This innovative study aims to develop the technology to transplant cells onto a 3D biocompatible valve scaffold that is capable of mimicking native valve. The work proposed is a ground breaking study that will encompass development of a new biomaterial, manufacture of scaffolds using the Fused Deposition Modelling ra ....Tissue Engineering of Human Heart Valve Grown In Vitro. Tissue engineering (TE) of heart valves is a new approach to cultivate a functional heart valve from human autologous cells. This innovative study aims to develop the technology to transplant cells onto a 3D biocompatible valve scaffold that is capable of mimicking native valve. The work proposed is a ground breaking study that will encompass development of a new biomaterial, manufacture of scaffolds using the Fused Deposition Modelling rapid prototyping process, hemodynamic optimisation and in vitro cell culture. This will advance our knowledge in cellular and scaffold technologies and may ultimately lead to the development of a TE heart valve.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989384
Funder
Australian Research Council
Funding Amount
$233,000.00
Summary
High-speed, three-dimensional, x-ray fluoroscopy for accurate measurement of human joint motion. This proposal addresses one of the most difficult and long-standing problems in the field of biomechanics: How can human joint motion be measured accurately and non-invasively during common activities such as walking, stair ambulation and running? Low-dose, high-speed, three-dimensional, x-ray fluoroscopy provides an excellent solution to this problem and, in so doing, can play a pivotal role in heal ....High-speed, three-dimensional, x-ray fluoroscopy for accurate measurement of human joint motion. This proposal addresses one of the most difficult and long-standing problems in the field of biomechanics: How can human joint motion be measured accurately and non-invasively during common activities such as walking, stair ambulation and running? Low-dose, high-speed, three-dimensional, x-ray fluoroscopy provides an excellent solution to this problem and, in so doing, can play a pivotal role in healthcare, through clinical gait analysis and gait rehabilitation (diagnosis, prevention and treatment of movement disorders); in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of physics-based animations for the video/digital games industry.Read moreRead less
Fluid dynamics and mechanical stress of tissue heart valves. Major problems with thrombo-embolic complications and leaflet failure and calcification still exist with bioprosthetic valves. Valves fabricated from polyether urethanes are efficient and can offer more resistance to calcification. No complete study on the haemodynamics and structure interactions is found in literature. Moreover, todate the effect of aortic wall motion on the blood flow has never been examined. A complete holistic ap ....Fluid dynamics and mechanical stress of tissue heart valves. Major problems with thrombo-embolic complications and leaflet failure and calcification still exist with bioprosthetic valves. Valves fabricated from polyether urethanes are efficient and can offer more resistance to calcification. No complete study on the haemodynamics and structure interactions is found in literature. Moreover, todate the effect of aortic wall motion on the blood flow has never been examined. A complete holistic approach to simulataneuosly simulating the fluid dynamics, the valve motion and the stress in a synthetic Polyether urethane valve is proposed. Cell adhesion study will also be carried out. The findings may yield to new insights into valve research.Read moreRead less
Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation. Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilag ....Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation. Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilage and will incorporate the unique structure of the dissimilar layers in articular cartilage. It will be used to study how these resist the propagation of an initiated crack and will offer significant insight into the desirable fracture properties of any replacement material for articular cartilage and will provide a basis for assessing replacement biomaterials.Read moreRead less
Computer simulation techniques to reduce the incidence of femoral fracture after hip replacement surgery. Australia's ageing population is driving an increase of 5% to 10% a year in the number of primary total hip replacements. We will move beyond conventional surgical techniques, to deliver the science for an accurate, reliable computer-based system that is significantly more accurate and reliable. Optimising implant selection criteria to better match patients' activity levels and bone physiolo ....Computer simulation techniques to reduce the incidence of femoral fracture after hip replacement surgery. Australia's ageing population is driving an increase of 5% to 10% a year in the number of primary total hip replacements. We will move beyond conventional surgical techniques, to deliver the science for an accurate, reliable computer-based system that is significantly more accurate and reliable. Optimising implant selection criteria to better match patients' activity levels and bone physiology and minimise revision rates; this has major implications for the national health budget and patients' quality of life. Our advances will allow the implementation of improved surgical techniques that minimise the risk of implant related bone failure.Read moreRead less