Mechanism Of Anoxic Iron Acquisition In Pathogenic Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$536,280.00
Summary
All organisms require iron for their survival, including all bacterial species. Bacterial pathogens growing in anaerobic environments, such as in our gut, gum, or tissue, sequester iron through the divalent iron transporter FeoB. We aim to divulge the mechanism of iron transport through FeoB by structural and functional studies, and thus provide a scaffold for a non-conventional antimicrobial target.
Characterising The Beta-catenin Nuclear Targeting Pathway In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$485,081.00
Summary
Bowel cancer is caused by inherited gene mutations that cause build-up of beta-catenin protein in the cell nucleus. Bowel cancer is the second largest cause of cancer deaths in Australia. We aim to study the mechanisms controlling beta-catenin accumulation in the nucleus. We will characterise new signalling pathways that control movement and activity of beta-catenin in the nucleus. This will yield insights into the role of beta-catenin in cancer and possible targets for therapy.
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Discovering the molecular controls of epigenetic inheritance . This project aims to investigate the way in which acquired traits can be inherited. The environment that an individual is exposed to can change the characteristics of not only that individual, but also their children and grandchildren. We do not yet understand the mechanisms by which this “epigenetic inheritance” occurs. Using interdisciplinary approaches, this project combines the power of the model organism Caenorhabditis elegans ....Discovering the molecular controls of epigenetic inheritance . This project aims to investigate the way in which acquired traits can be inherited. The environment that an individual is exposed to can change the characteristics of not only that individual, but also their children and grandchildren. We do not yet understand the mechanisms by which this “epigenetic inheritance” occurs. Using interdisciplinary approaches, this project combines the power of the model organism Caenorhabditis elegans with cutting-edge single molecule microscopy techniques to determine the molecular mechanisms by which the environment can impact future generations. This should ultimately provide society with the means to harness the power of epigenetics.Read moreRead less
Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms t ....Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.Read moreRead less
In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-ski ....In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-skilled techniques, including cryo-electron microscopy and single-molecule imaging and holds ancillary benefits to postgraduate students. Anticipated outcomes include influential publications, building a critical mass of expertise in Australia and fostering international collaborations with Australia at the epicentre.Read moreRead less
Neutral hydrogen and galaxy assembly in the distant Universe. This research will produce a snapshot of hydrogen gas in the Universe 6-7 billion years ago. These results, together with galaxy formation models, will tell us how galaxies are assembled to make the beautiful spirals we see today. This project is only possible because of rapid advances in programmable chip technology, part of the massive increase in the speed and complexity of integrated circuit devices.
Our Galaxy: the last hundred million years. Star formation and evolution are the fundamental processes which energize a galaxy and recycle the interstellar medium. In our Galaxy, we have the opportunity to study these processes in great detail. This project uses sensitive radio continuum images from the Molonglo Observatory Synthesis Telescope to discover how this energizing and enrichment occurs. We will use innovative machine learning techniques to identify a potentially new population of Gala ....Our Galaxy: the last hundred million years. Star formation and evolution are the fundamental processes which energize a galaxy and recycle the interstellar medium. In our Galaxy, we have the opportunity to study these processes in great detail. This project uses sensitive radio continuum images from the Molonglo Observatory Synthesis Telescope to discover how this energizing and enrichment occurs. We will use innovative machine learning techniques to identify a potentially new population of Galactic sources and to patrol a new domain in source variability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238884
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
Development of the CANGAROO III Very High Energy Gamma-ray telescope. This international project will explore the only part of the electromagnetic spectrum yet to be subjected to detailed astronomical study. CANGAROO III will span the energy range from ~100GeV to >10TeV, expanding upwards the range of satellite observations, and downwards the range accessible from previous ground-based systems. Gamma-ray observations have opened a new window on the universe and it is clear that there is much to ....Development of the CANGAROO III Very High Energy Gamma-ray telescope. This international project will explore the only part of the electromagnetic spectrum yet to be subjected to detailed astronomical study. CANGAROO III will span the energy range from ~100GeV to >10TeV, expanding upwards the range of satellite observations, and downwards the range accessible from previous ground-based systems. Gamma-ray observations have opened a new window on the universe and it is clear that there is much to be discovered with this new instrument. This project will provide an Australian infrastructure contribution to support the multi-million dollar contribution of our Japanese partners, and thus provide Australian access to a key astrophysical field at very modest cost.Read moreRead less
Improving optical data storage and micromachining technology through better modelling and characterisation of their laser beams. The laser sources generally do not have simple (Gaussian) distributions. The applicant has recently developed a model, describing free propagation of complex (non-Gaussian) laser beams. This project seeks to develop a comprehending model for laser beams propagation through complex optical systems. The effects of various optical elements will be defined employing a no ....Improving optical data storage and micromachining technology through better modelling and characterisation of their laser beams. The laser sources generally do not have simple (Gaussian) distributions. The applicant has recently developed a model, describing free propagation of complex (non-Gaussian) laser beams. This project seeks to develop a comprehending model for laser beams propagation through complex optical systems. The effects of various optical elements will be defined employing a novel method known as SAFE (Stable Aggregate of Flexible Elements) which is a compromise between geometrical and physical optics. Applying this model to micromachining and optical data storage (ODS), which need high beam quality (low divergence and good focussibility), enable accurate predictive capability critical to the optimisation of micromachining and ODS designs.Read moreRead less