Discovering the molecular controls of epigenetic inheritance . This project aims to investigate the way in which acquired traits can be inherited. The environment that an individual is exposed to can change the characteristics of not only that individual, but also their children and grandchildren. We do not yet understand the mechanisms by which this “epigenetic inheritance” occurs. Using interdisciplinary approaches, this project combines the power of the model organism Caenorhabditis elegans ....Discovering the molecular controls of epigenetic inheritance . This project aims to investigate the way in which acquired traits can be inherited. The environment that an individual is exposed to can change the characteristics of not only that individual, but also their children and grandchildren. We do not yet understand the mechanisms by which this “epigenetic inheritance” occurs. Using interdisciplinary approaches, this project combines the power of the model organism Caenorhabditis elegans with cutting-edge single molecule microscopy techniques to determine the molecular mechanisms by which the environment can impact future generations. This should ultimately provide society with the means to harness the power of epigenetics.Read moreRead less
Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms t ....Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.Read moreRead less
In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-ski ....In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-skilled techniques, including cryo-electron microscopy and single-molecule imaging and holds ancillary benefits to postgraduate students. Anticipated outcomes include influential publications, building a critical mass of expertise in Australia and fostering international collaborations with Australia at the epicentre.Read moreRead less
Neutral hydrogen and galaxy assembly in the distant Universe. This research will produce a snapshot of hydrogen gas in the Universe 6-7 billion years ago. These results, together with galaxy formation models, will tell us how galaxies are assembled to make the beautiful spirals we see today. This project is only possible because of rapid advances in programmable chip technology, part of the massive increase in the speed and complexity of integrated circuit devices.
Our Galaxy: the last hundred million years. Star formation and evolution are the fundamental processes which energize a galaxy and recycle the interstellar medium. In our Galaxy, we have the opportunity to study these processes in great detail. This project uses sensitive radio continuum images from the Molonglo Observatory Synthesis Telescope to discover how this energizing and enrichment occurs. We will use innovative machine learning techniques to identify a potentially new population of Gala ....Our Galaxy: the last hundred million years. Star formation and evolution are the fundamental processes which energize a galaxy and recycle the interstellar medium. In our Galaxy, we have the opportunity to study these processes in great detail. This project uses sensitive radio continuum images from the Molonglo Observatory Synthesis Telescope to discover how this energizing and enrichment occurs. We will use innovative machine learning techniques to identify a potentially new population of Galactic sources and to patrol a new domain in source variability.Read moreRead less
Improving optical data storage and micromachining technology through better modelling and characterisation of their laser beams. The laser sources generally do not have simple (Gaussian) distributions. The applicant has recently developed a model, describing free propagation of complex (non-Gaussian) laser beams. This project seeks to develop a comprehending model for laser beams propagation through complex optical systems. The effects of various optical elements will be defined employing a no ....Improving optical data storage and micromachining technology through better modelling and characterisation of their laser beams. The laser sources generally do not have simple (Gaussian) distributions. The applicant has recently developed a model, describing free propagation of complex (non-Gaussian) laser beams. This project seeks to develop a comprehending model for laser beams propagation through complex optical systems. The effects of various optical elements will be defined employing a novel method known as SAFE (Stable Aggregate of Flexible Elements) which is a compromise between geometrical and physical optics. Applying this model to micromachining and optical data storage (ODS), which need high beam quality (low divergence and good focussibility), enable accurate predictive capability critical to the optimisation of micromachining and ODS designs.Read moreRead less