Mapping Neurodevelopmental Disorders In A Zebrafish Model
Funder
National Health and Medical Research Council
Funding Amount
$2,760,520.00
Summary
The way in which the brain develops differently in neurodevelopmental disorders such as autism is hard to reveal in humans, but can be addressed in a zebrafish model. Using cutting-edge imaging and computational techniques, this project will investigate how neural representations of the world develop differently between normal zebrafish and zebrafish mutant for a gene that causes autism. This will provide new insights into the mechanisms of altered circuit development in autism.
Using Protein Structure And Dynamics To Facilitate Drug Discovery
Funder
National Health and Medical Research Council
Funding Amount
$1,512,250.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the human genome, and drugs targeting these receptors account for 35% of marketed drugs. This project aims to determine atomic-level structural information of how drugs bind and specifically interact with therapeutically relevant GPCRs. Outcomes of this research will facilitate the design of future development of selective and effective drugs.