Australian Laureate Fellowships - Grant ID: FL200100220
Funder
Australian Research Council
Funding Amount
$3,364,492.00
Summary
Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-ass ....Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.Read moreRead less
Designing a Holistic Model of Advice to Improve Retirement Planning. We aim to improve retirement planning through the design and application of a new model integrating financial advice with career and health planning to optimise financial and psychological outcomes. We will test a multidisciplinary, holistic model of advice combining specialist knowledge in careers, health, and finances. Expected outcomes of the project include evaluating the use of a broader range of experts during retirement ....Designing a Holistic Model of Advice to Improve Retirement Planning. We aim to improve retirement planning through the design and application of a new model integrating financial advice with career and health planning to optimise financial and psychological outcomes. We will test a multidisciplinary, holistic model of advice combining specialist knowledge in careers, health, and finances. Expected outcomes of the project include evaluating the use of a broader range of experts during retirement planning and developing a model for the future training and development of financial advisers.By optimising the timing of workplace exit, we aim to decrease reliance on pensions and encourage earlier and on-going engagement in the retirement planning process. This will provide significant social and economic benefits.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100771
Funder
Australian Research Council
Funding Amount
$278,780.00
Summary
Automated system for bone texture analysis of osteoarthritis in hand radiographs. Early detection and prediction of hand osteoarthritis are not feasible by current methods of visual grading of hand radiographs. This project will develop a novel, fully automated system for selection of bone texture regions on hand radiographs and their analysis to address this problem.
Neural plasticity in older adult human vision. This project aims to expand our understanding of age related changes in brain function, specifically plasticity. The project will increase knowledge of the role of an inhibitory neurotransmitter GABA in visual plasticity. Expected outcomes include new knowledge regarding the regulation of brain function in adulthood, enabling future research and planning for societal benefit to older Australia.
Developing a disability policy model to target the prevention or reduction of limitations on functioning and wellbeing. With the ageing of Australian society the challenge for public health is shifting from preventing death and disease onset to supporting healthy and productive ageing. The disability policy model will allow cost-effective targeting of interventions to reduce or prevent onset of disability or reduce its severity particularly among older Australians.
Characterisation of deficits in driving performance and self-regulation practices among older drivers with bilateral cataract. Despite the high prevalence of cataract among the older population, there is limited evidence on the impact of first and second eye cataract surgery on driving outcomes. This prospective study will use naturalistic in-vehicle driver monitoring devices and a state-of–the-art driving simulator to examine the association between clinical measures of vision, refractive manag ....Characterisation of deficits in driving performance and self-regulation practices among older drivers with bilateral cataract. Despite the high prevalence of cataract among the older population, there is limited evidence on the impact of first and second eye cataract surgery on driving outcomes. This prospective study will use naturalistic in-vehicle driver monitoring devices and a state-of–the-art driving simulator to examine the association between clinical measures of vision, refractive management, driving patterns, self-regulation and driving performance for bilateral cataract patients before first eye surgery, between surgeries and after second eye surgery. The results will inform Ophthalmology and licensing authorities regarding surgical and refractive management as well as fitness to drive assessments for older drivers with bilateral cataract.Read moreRead less
The impact of first and second eye cataract surgery on falls and utilisation of mental health services among older Australians. This population-based study will investigate the association and timing of cataract surgery and health-related costs in reducing the incidence of falls and utilisation of mental health services following first and second eye cataract surgery. Evidence-based recommendations will be developed to improve safety for older Australians.
Investigating the health benefits of volunteering by seniors. For humanitarian and economic reasons, it is important to promote health-enhancing behaviours among older people to optimise their well-being. Volunteering constitutes one such behaviour. While there is some evidence that older people benefit from volunteering, there is inadequate data for policy development purposes. This project will quantify the physical and mental outcomes of seniors’ engagement in volunteering activities to asses ....Investigating the health benefits of volunteering by seniors. For humanitarian and economic reasons, it is important to promote health-enhancing behaviours among older people to optimise their well-being. Volunteering constitutes one such behaviour. While there is some evidence that older people benefit from volunteering, there is inadequate data for policy development purposes. This project will quantify the physical and mental outcomes of seniors’ engagement in volunteering activities to assess the potential to enhance their health while providing much-needed labour inputs to the Australian economy. The results will also suggest ways to encourage older people to engage in volunteering by identifying effective ways to communicate the benefits to this audience.Read moreRead less
Modelling community preferences for health policy: how choice experiments can inform the organisation of acute health services for older Australians. This work will provide vital information on community preferences to inform health policy regarding how we should best organise acute healthcare for older Australians. It addresses one of the most pressing health policy issues in Australia: how to maintain a sustainable, equitable and responsive health care system, in the face of an ageing populati ....Modelling community preferences for health policy: how choice experiments can inform the organisation of acute health services for older Australians. This work will provide vital information on community preferences to inform health policy regarding how we should best organise acute healthcare for older Australians. It addresses one of the most pressing health policy issues in Australia: how to maintain a sustainable, equitable and responsive health care system, in the face of an ageing population.Read moreRead less
Visual field impairment and injury: A population-based study. This project aims to link a large-scale ophthalmic database of visual field tests to population-based injury data which includes police-reported crash data, hospitalisation, death and trauma data in people aged over 60 years. The identification of individuals with high risk visual fields will enable the development of targeted interventions at the local, national and international level to prevent injuries due to visual field loss. Si ....Visual field impairment and injury: A population-based study. This project aims to link a large-scale ophthalmic database of visual field tests to population-based injury data which includes police-reported crash data, hospitalisation, death and trauma data in people aged over 60 years. The identification of individuals with high risk visual fields will enable the development of targeted interventions at the local, national and international level to prevent injuries due to visual field loss. Significant benefits include a reduction in the number of injuries and consequent reductions in personal harm and health care demands.Read moreRead less