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The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies ....Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies of hydro-climate forecasting, with federal, state and regional water agencies.Read moreRead less
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Novel water treatment processes. The objective of this project is the discovery of novel methods for the treatment and reuse of water for both industrial and household applications. Improved treatment systems with the potential for water reuse offer significant improvements to our overall water management potential. The first part of the project is designed to focus on the study of hot bubble column evaporators for solute decomposition, sterilisation and the de-watering of heavily contaminated i ....Novel water treatment processes. The objective of this project is the discovery of novel methods for the treatment and reuse of water for both industrial and household applications. Improved treatment systems with the potential for water reuse offer significant improvements to our overall water management potential. The first part of the project is designed to focus on the study of hot bubble column evaporators for solute decomposition, sterilisation and the de-watering of heavily contaminated industrial wastewater. The second part would be based on the study of a suitable depth filter medium for the treatment of partially treated household sewage water. This is designed to form part of an on-site household sewage water treatment and reuse system which is currently being developed.Read moreRead less
Delivering robust hydrological predictions for Australia’s water challenges. This project aims to build a virtual hydrological laboratory to identify the best hydrological models that maximise predictive performance in a range of catchments, accounting for their dominant hydrological processes and data availability. New process-informed hydrological model structures will be developed using this virtual laboratory to embody our best understanding of hydrological processes and data from real catch ....Delivering robust hydrological predictions for Australia’s water challenges. This project aims to build a virtual hydrological laboratory to identify the best hydrological models that maximise predictive performance in a range of catchments, accounting for their dominant hydrological processes and data availability. New process-informed hydrological model structures will be developed using this virtual laboratory to embody our best understanding of hydrological processes and data from real catchments. The expected outcomes include major improvements in hydrological predictions for Australian catchments. This project will provide major benefits to irrigators, water authorities and engineers, who rely on hydrological predictions for sustainable water management in the highly-variable, semi-arid Australian climate.Read moreRead less
Effect of faults and barriers on groundwater flow and solute transport. This project will address the role of faults and dykes on groundwater flow and solute transport. Faults and dykes can act as barriers to groundwater flow, yet faults can also be conduits for flow through otherwise impermeable layers. Understanding their role is critical to assessing the impacts of mining, unconventional gas and water resource developments. This project expects to develop new methods to quantify groundwater f ....Effect of faults and barriers on groundwater flow and solute transport. This project will address the role of faults and dykes on groundwater flow and solute transport. Faults and dykes can act as barriers to groundwater flow, yet faults can also be conduits for flow through otherwise impermeable layers. Understanding their role is critical to assessing the impacts of mining, unconventional gas and water resource developments. This project expects to develop new methods to quantify groundwater flow through and along faults and dykes by combining geological, hydraulic and geochemical approaches with detailed 3D numerical models. The expected outcome will be an improved understanding of the role of faults and barriers in subsurface hydrology, and an improved ability to model complex groundwater systems.Read moreRead less
Dynamics of Suppressed Mixing Regimes in Australian Rivers. This study aims to further the fundamental science of turbulent mixing in the context of flow in Australian rivers. The focus is on prolonged low flow conditions which when coupled with warm surface temperatures cause the water column to become thermally stratified which then suppresses turbulent mixing. The extreme scale of the river systems has made investigating the true dynamics of the strongly stratified mixing regimes particularly ....Dynamics of Suppressed Mixing Regimes in Australian Rivers. This study aims to further the fundamental science of turbulent mixing in the context of flow in Australian rivers. The focus is on prolonged low flow conditions which when coupled with warm surface temperatures cause the water column to become thermally stratified which then suppresses turbulent mixing. The extreme scale of the river systems has made investigating the true dynamics of the strongly stratified mixing regimes particularly challenging. By taking world first in-situ measurements of turbulent mixing and undertaking high resolution numerical simulations this study will provide definitive data which will allow correct characterization of the mixing regimes and how they are associated with river flow conditions.Read moreRead less