Antioxidants Vitamin C And Vitamin E For The Prevention Of Pre-eclampsia - A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$696,750.00
Summary
Women who develop hypertension in pregnancy have a higher risk of complications in pregnancy and their babies are often born smaller than average and earlier. An initial trial to women at high risk of pre-eclampsia suggest that vitamin C and vitmin E supplements may decrease both reduce the risk of developing hypertension in pregnancy and the risk of the infant being born small for dates. These encouraging results need assessment in the Australian population. This study assesses the value of wom ....Women who develop hypertension in pregnancy have a higher risk of complications in pregnancy and their babies are often born smaller than average and earlier. An initial trial to women at high risk of pre-eclampsia suggest that vitamin C and vitmin E supplements may decrease both reduce the risk of developing hypertension in pregnancy and the risk of the infant being born small for dates. These encouraging results need assessment in the Australian population. This study assesses the value of women taking vitamin C and vitamin E supplements during the antenatal period to decrease the risk of developing hypertension during pregnancy and poor fetal growth. Such an easy and inexpensive therapy, if effective, would be an important advance.Read moreRead less
The D-Health Trial: A Large-scale Population-based Trial Of Vitamin D Supplementation For Improving The Health Of Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$2,591,860.00
Summary
The D-Health Trial is a randomised placebo-controlled trial of vitamin D supplementation for improving the health of older Australian adults. Over 21,000 people were recruited and randomised to monthly doses of vitamin D or placebo. This grant will enable completion of the planned 5 years of supplementation and long-term follow-up of mortality and cancer. The results of the trial will inform decisions about food fortification and/or supplementation with vitamin D.
Primary Prevention Of Infant Food Allergy: A Randomised Controlled Trial Of Postnatal Vitamin D Supplementation
Funder
National Health and Medical Research Council
Funding Amount
$1,723,793.00
Summary
Low vitamin D has been linked to a range of health conditions but, unlike many countries, Australia does not recommend supplementing infants with vitamin D. Good quality research on the effectiveness of vitamin D supplementation to prevent disease is lacking. Our trial of 2330 infants examines whether a daily dose of vitamin D prevents the development of food allergy. Vitamin D is safe and low cost. Infant supplementation may be the first simple strategy to reduce this common childhood condition
D-Health: A Randomised Trial Of Vitamin D For Prevention Of Cancer And Mortality
Funder
National Health and Medical Research Council
Funding Amount
$2,930,705.00
Summary
There is good evidence that vitamin D is important for maintaining healthy bones. There is now a body of work suggesting that it may play a role in other diseases such as cancer, but there is not yet sufficient information to warrant screening the population to determine their vitamin D levels or recommending routine supplementation. We plan to conduct a large-scale randomised placebo-controlled trial in which we will assess the effect of vitamin D supplementation on mortality, cancer incidence ....There is good evidence that vitamin D is important for maintaining healthy bones. There is now a body of work suggesting that it may play a role in other diseases such as cancer, but there is not yet sufficient information to warrant screening the population to determine their vitamin D levels or recommending routine supplementation. We plan to conduct a large-scale randomised placebo-controlled trial in which we will assess the effect of vitamin D supplementation on mortality, cancer incidence and many other common diseases such as diabetes.Read moreRead less
Creating An Evidence Base For Balanced Sun Exposure Messages For Optimal Health
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Both too much and too little sun exposure result in risks to health, but there are considerable uncertainties in our understanding of the detail, for both risks and benefits. This project focuses on key research gaps that need to be filled before a balanced sun exposure message, appropriate for Australians of different skin types and living in different locations, can be developed and disseminated.
The FREEDOM Study: A RCT Of Sunlight And Calcium To Reduce Vitamin D Deficiency In Older People In Residential Care
Funder
National Health and Medical Research Council
Funding Amount
$838,972.00
Summary
The proposed study emanates from a large ongoing epidemiological study on falls and fractures in the elderly (the FREE study). Falls and fractures are major problems in the elderly. This is the genesis for the FREEDOM (Falls Risk Epidemiology: Effect of vitamin D on skeletal Outcomes and other Measures) intervention study. The FREEDOM study will evaluate the effect of a public health strategy to reduce falls and fractures in older people living in residential care (namely appropriate sun light e ....The proposed study emanates from a large ongoing epidemiological study on falls and fractures in the elderly (the FREE study). Falls and fractures are major problems in the elderly. This is the genesis for the FREEDOM (Falls Risk Epidemiology: Effect of vitamin D on skeletal Outcomes and other Measures) intervention study. The FREEDOM study will evaluate the effect of a public health strategy to reduce falls and fractures in older people living in residential care (namely appropriate sun light exposure and calcium supplementation) in a randomised trial. The primary endpoints of this study will be reduction in falls and change in vitamin D levels. Other endpoints will be change in motor function, mood, bone turnover and fracture incidence. The proposed public health strategy to be examined is readily transferable to routine practice and would have very good feasibility for easy implementation and are generally applicable to the residential care setting, where the study will be conducted. Moreover the proposed approach would be low in cost and does not depend on other health system input. Potentially large numbers of people would benefit from the better understanding of simple methods of securing improved vitamin D status.Read moreRead less