Investigations Of Strategies To Address The Long Term Maintenance Of Bone Density In Younger Women: Fracture Risk Feedback And Vitamin D.
Funder
National Health and Medical Research Council
Funding Amount
$223,155.00
Summary
Fractures in the elderly are an important health problem. We previously studied 470 young women, informing them of their level of fracture risk and providing osteoporosis education. Women at higher risk more often started calcium supplements, increased physical activity, and had higher bone density after 2 years than those at low risk. We will test the same women after 11 years to see if these improvements persist and so might reduce fractures in old age. We will also assess the effects of vitam ....Fractures in the elderly are an important health problem. We previously studied 470 young women, informing them of their level of fracture risk and providing osteoporosis education. Women at higher risk more often started calcium supplements, increased physical activity, and had higher bone density after 2 years than those at low risk. We will test the same women after 11 years to see if these improvements persist and so might reduce fractures in old age. We will also assess the effects of vitamin D on bone health in these women.Read moreRead less
Does Vitamin D Supplementation Prevent Progression Of Knee Osteoarthritis? A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,016,758.00
Summary
Observational evidence suggests that vitamin D deficiency may have a role in the causes of osteoarthritis (OA) and there are biologically plausible mechanisms to explain this. There is, however, no evidence which shows that intervening with vitamin D supplementation can slow the progression of OA. This study will compare knee OA structural changes in patients receiving vitamin D supplementation with those receiving a placebo. Use of MRI will provide sensitive measures of knee OA changes.
Using Magnetic Resonance Imaging (MRI) To Improve Understanding Of Knee Osteoarthritis And Develop Effective Therapeutic Treatments
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Osteoarthritis is the most common form of arthritis and is increasing markedly due to an ageing population. This program of research uses magnetic resonance imaging (MRI) to improve our understanding about knee osteoarthritis. It will examine knee structural change over time using unique 10-year follow-up MRI measures from a pre-existing case-control study. This program of research will also examine two randomised controlled trials which aim to evaluate therapeutic treatments for the disease.