Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between ....Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between these factors is unknown. The outcomes of the current grant will provide the first evidence of that link, thus providing deeper understanding of the neurophysiological mechanisms of these disorders, which could eventuate in the creation of more beneficial treatments. Read moreRead less
Novel dopamine pathways underlying motivated behaviours. Rewards such as food, sex and social media are seeked on daily basis. Neurological and psychological basis of learning and memory of reward processing behaviour. This project maps real time neural activity during reward processing in two novel brain regions. It has the potential to revolutionize the understanding of the brain mechanisms in reward processing. The biological data obtained can be directly integrated into computational modelli ....Novel dopamine pathways underlying motivated behaviours. Rewards such as food, sex and social media are seeked on daily basis. Neurological and psychological basis of learning and memory of reward processing behaviour. This project maps real time neural activity during reward processing in two novel brain regions. It has the potential to revolutionize the understanding of the brain mechanisms in reward processing. The biological data obtained can be directly integrated into computational modelling approaches to benefit reward processing algorithms for learning behaviours in humans or artificial intelligence. This project will fuel the understanding of algorithms driving social media platforms and consumer consumption, hence driving economic and technological progress in Australia.Read moreRead less
Investigating the role of Zona Incerta RXFP3+ cells in learning and memory. Learning and memory are fundamental to human and animal behaviour. We identified a specific population of cells in the zona incerta of the brain, where activation inhibits expression of memory, and facilitates the acquisition of new learning. Aside from our observations, nothing is currently known about the anatomy and function of these cells. This project aims to map how they connect to the rest of the brain, to observe ....Investigating the role of Zona Incerta RXFP3+ cells in learning and memory. Learning and memory are fundamental to human and animal behaviour. We identified a specific population of cells in the zona incerta of the brain, where activation inhibits expression of memory, and facilitates the acquisition of new learning. Aside from our observations, nothing is currently known about the anatomy and function of these cells. This project aims to map how they connect to the rest of the brain, to observe how these connections are recruited during learning and memory, and then to test their function experimentally. The outcomes will extend the known neural circuitry that controls learning by defining how and where these unexplored pathways fit within it; thus advancing knowledge regarding neural regulation of behaviour.
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Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as pred ....Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as predator cues, enhance avoidance behaviour. This project will uncover the neural circuitry and endocrine mechanisms through which hunger influences hypothalamic threat-detecting circuits that suppress food intake. These studies provide a new hypothalamic model to understand risk/reward decision in the brain.Read moreRead less