Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that ....Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that the partnership between UTAS and Bestenbalt LLC is a critical step in the development of these exciting research discoveries into commercially viable outcomes for the Australian Biotechnology Industry and the broader Australian community.Read moreRead less
Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These a ....Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These are significant community issues in both economical and social terms. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest cellular processes associated with aging or disease of the brain, and will provide clues to promoting healthy aging.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson' ....The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson's disease patients whose timing performance is impaired due to dopaminergic dysfunction. We expect TMS inhibitory effects to induce predictable performance trends, providing support for the accumulator model and the key role of the SMA in timing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882701
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Establishment of a confocal/multiphoton microscope for imaging of living systems. This facility will allow us to study the dynamic changes in living systems, from the smallest unicellular organisms in the ocean through to the sophisticated neural networks of the living brain. Not only will this imaging facility allow us to understand how living systems work, we will also be able to explore the dynamic changes that underlie human disease and injury.
Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will pro ....Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will provide information for the development of specific intervention techniques to improve motor function in these groups.Read moreRead less
Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a re ....Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a result of aging, degenerative disease, or brain damage. This research will provide a foundation upon which rehabilitation strategies can be developed for the movement impaired.Read moreRead less
Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is ....Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is an important lifestyle factor as humans age and deficits in coordinated muscle activity will increase the risk of falls which are the leading cause of injury in elderly adults. Identification of changes in brain processes involved in interlimb coordination will allow for the development of strategies to improve motor functions in the aged.Read moreRead less
Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to ....Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to identify the critical components underlying the effectiveness of an intervention involving the pratice of actions bilaterally and simultaneously.Read moreRead less