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Dynamic Imaging Of The Immune Response In Lymph Nodes By Two-photon Microscopy
Funder
National Health and Medical Research Council
Funding Amount
$79,514.00
Summary
Despite the enormous contribution of vaccination to the prevention of human disease and suffering, little is known about the laws that govern the selection and survival of B cells during the response to infection or vaccination. Our research projects aim to integrate several cutting-edge technologies, including two-photon microscopy, in order to understand the cellular and molecular basis of immunity.
Signal Integration During The Early B Cell/CD4+ T Cell Interactions In T-dependent Antibody Responses
Funder
National Health and Medical Research Council
Funding Amount
$128,783.00
Summary
Effective humoral immunity results from the complex interaction of B and T lymphocytes. STAT3, CD40L, SAP and ICOS are molecules that are involved in this interaction. Genetic mutations of these molecules result in well defined primary immunodeficiencies underscoring their importance. This study aims to characterise the integration of these early signals as well as other inputs that B cells receive and characterise the CD4+ cells that provide this help.
Managing Depression Within Low Vision Rehabilitation Services: The Effectiveness Of Integrating An Evidence-based Therapy ‘Problem-Solving Therapy For Primary Care’ On Depression, Quality Of Life And Service Utilisation In Those With Low Vision
Funder
National Health and Medical Research Council
Funding Amount
$92,785.00
Summary
This research will evaluate the integration of an evidence-based treatment for depression into low vision rehabilitation services. It is anticipated that this new program will lead to sustained improvements in participants’ quality of life and mental health. This is the first time a system to manage depression has been implemented into low vision services worldwide and if successful this intervention could be suitable for application to other chronic health conditions.
There is strong evidence of an increased falls risk associated with cataract, a primary cause of vision impairment in older Australians. This research will determine factors contributing to increases in falls risk in people aged 70 years and older with cataract before surgery, between first and second eye surgery, and after second eye surgery. The findings can inform the optimal management of older people with cataract and limit negative health impacts of cataract-related injury and falls.