Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
I am a molecular virologist researching the host response to hepatitis C virus (HCV) infection with the aim of understanding how the liver clears HCV infection. An understanding of this process will hopefully lead to novel antiviral strategies to combat not only HCV but a broad range of other viral infections.
A Pragmatic Randomised Clinical Trial Of Nicotine Vaporisers Added To Smoking Cessation Treatment For Priority Populations Living With Comorbidities
Funder
National Health and Medical Research Council
Funding Amount
$1,499,145.00
Summary
Smoking is a leading cause of early death for people with certain health conditions because they are more likely to smoke and are also at greater risk of tobacco-related disease. This clinical trial will test whether encouraging people living with Hepatitis C Virus, people on opiate substitution therapy and people living with HIV who smoke to use nicotine vaporisers long-term, in addition to current smoking cessation treatments, will help them to stay abstinent from smoking.
Discovery Early Career Researcher Award - Grant ID: DE120102821
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Molecular genetic adaptive processes in natural co-evolution between rabbits and the rabbit haemorrhagic disease virus. This project will use extensive sampling and long-term field data to reveal ongoing co-evolutionary mechanisms behind the increasing resistance of pest Australian wild rabbits against a viral pathogen. The results will increase the understanding of evolutionary mechanisms in nature and will provide basic information for biological pest control of rabbits.
Hepatitis C affects a quarter of a million Australians, causing insidious but progressive liver disease which culminates in liver failure or cancer. There is no vaccine and prevention programs have limited effectiveness, but new antiviral therapies now offer high rates of cure. This Program will evaluate strategies to improve the health of those affected and prevent new infections by better understanding of the virus and the body’s immune response, including scarring and liver cancer formation.
Interventions To Improve Outcomes For Young Aboriginal And Torres Strait Islander People In Sexually Transmissible Infections Blood Borne Viruses And For People Using Methamphetamines
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This ECF will enable research to be carried out in the domains of sexually transmissible infections (STI) and blood borne viruses (BBV) and specifically methamphetamine (MA) use in Aboriginal communities nationally. Specific research outcomes will be the establishment of an Aboriginal primary health care and behavioural surveillance network for STIs/BBVs in nationally dispersed clinical hubs (CRE), and an improved understanding of interventions to address MA in Aboriginal communities.
What drives parasite spread through social networks: lessons from lizards. Australia's biodiversity is continually threatened by new epidemics of local and foreign diseases and parasites. This project will enhance our understanding of how these diseases spread, allowing more effective controls to be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
Parasite transmission through social networks in the pygmy bluetongue lizard. Australia's biodiversity is continually threatened by new epidemics of diseases and parasites, some local, others from overseas. This project will provide information on how they spread so that more effective management of these diseases can be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.