Memory CD4 T Cells That Harbour The Reservoir Of Latent HIV Infection: Their Antigen Specificity, Function And Frequency Of Antigen-drivien Reactivation
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Current antiretroviral therapy for HIV-1 infection is able to suppress viral replication, but cannot eradicate it completely. Upon cessation of antiviral therapy, viral recrudescence is prompt, and most likely arises from latent reservoirs of HIV in various cellular compartments. The aim of this research is to characterise which subsets of CD4 T cells that are the target of HIV infection harbour HIV infection, including describing their function and individual target antigen specificities.
Viral Reservoirs:Role Of Naive T-cells In The Pathogeneisis Of T-cell Decline And Longterm Persistence Of HIV Infection.
Funder
National Health and Medical Research Council
Funding Amount
$85,716.00
Summary
Despite dramatic advances in treatment for HIV infection, HIV cannot be cured. The main reason why cure is not possible is because HIV can persist in long lived cells and these infected cells are not recognised by the immune system. This project will examine the role of a particular type of infection fighting cell, the naive T-cell, in long term persistence of HIV. The project will determine how naive T-cells are infected with HIV and what happens to these cells following HIV treatment.