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Characterisation and Stability of ISCOM Vaccines. ISCOMS® are particles comprising saponin, cholesterol and phospholipids which when mixed with proteins form potent vaccines. When proteins are associated with ISCOMs® a variety of different sized particles with various surface chemistries can be formed. This project aims to understand the physico-chemical mechanisms governing ISCOM® formation. This understanding will allow development of methods for controlling the size, characteristics and long- ....Characterisation and Stability of ISCOM Vaccines. ISCOMS® are particles comprising saponin, cholesterol and phospholipids which when mixed with proteins form potent vaccines. When proteins are associated with ISCOMs® a variety of different sized particles with various surface chemistries can be formed. This project aims to understand the physico-chemical mechanisms governing ISCOM® formation. This understanding will allow development of methods for controlling the size, characteristics and long-term stability of these particles. In addition the size and surface chemistry of the particles will be correlated with their effectiveness as vaccines. Both these outcomes will support the ongoing commercial development of ISCOM®-based vaccines at CSL.Read moreRead less
A Physicochemical Approach for Optimizing Drug Delivery from BioSilicon. By applying modern techniques and a multidisciplinary approach, this research will develop an understanding of drug loading of BioSiliconTM at a molecular level. This novel class of nano-structured biomaterial has exciting potential for developing a range of controllable drug delivery systems. Existing medical applications of BioSilicon deliver only small molecules for very specialised uses. Current research has not focused ....A Physicochemical Approach for Optimizing Drug Delivery from BioSilicon. By applying modern techniques and a multidisciplinary approach, this research will develop an understanding of drug loading of BioSiliconTM at a molecular level. This novel class of nano-structured biomaterial has exciting potential for developing a range of controllable drug delivery systems. Existing medical applications of BioSilicon deliver only small molecules for very specialised uses. Current research has not focused on understanding the pore structure and how it can be adapted for special applications. Our research will create new drug delivery systems with many innovative applications in medical, veterinary and bio-diagnostics fields. The medical and socio-economic impacts will be internationally significant.Read moreRead less
Disulfide Cross-linked Hollow Polymer Capsules for Drug Delivery. The project is expected to deliver an un-paralleled drug delivery opportunity which will benefit the pharmaceutical industry, biomedical science and biotechnology. Young scientists will be trained bringing about skilled workers for Australian science and industry. The project will build on the existing as well as establish new collaborations between scientific institutions and industry. The project will result in novel intellectua ....Disulfide Cross-linked Hollow Polymer Capsules for Drug Delivery. The project is expected to deliver an un-paralleled drug delivery opportunity which will benefit the pharmaceutical industry, biomedical science and biotechnology. Young scientists will be trained bringing about skilled workers for Australian science and industry. The project will build on the existing as well as establish new collaborations between scientific institutions and industry. The project will result in novel intellectual property on which new technologies and spin-off companies will emerge, leading to increased employment opportunities in Australia and investment in Australian science and industry.Read moreRead less
Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons. This project will lead to a more efficient and reliable drug delivery system to treat Huntington's disease. The insights and technology gained from this project will be directly applicable for many human diseases, both within and outside the central nervous system. This project will make a major contribution to the ARC's goal of maintaining good health and promises to significantly reduce the financial and psychologica ....Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons. This project will lead to a more efficient and reliable drug delivery system to treat Huntington's disease. The insights and technology gained from this project will be directly applicable for many human diseases, both within and outside the central nervous system. This project will make a major contribution to the ARC's goal of maintaining good health and promises to significantly reduce the financial and psychological burdens to patients' family and community. This project will encourage inter-disciplinary approaches to research and train highly skilled researchers both in neuroscience and nanobiotechnology to advance Australia's industrial competitiveness.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775612
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the de ....Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the development of next-generation medicines, implants, optical devices and surface coatings, further strengthening Australia's formidable reputation in these areas.Read moreRead less
Nanoporous bioaffinity adsorbents for separations in the pharmaceutical industry. This proposal aims to develop new high performance adsorbents for bioprocess engineering based on templated nanoporous silica materials. This research will lead to significant advances in advanced materials and adsorbent technology, downstream processing for the biotechnology industries, and understanding of highly specific affinity interactions used for difficult bioseparations. It will have important benefits for ....Nanoporous bioaffinity adsorbents for separations in the pharmaceutical industry. This proposal aims to develop new high performance adsorbents for bioprocess engineering based on templated nanoporous silica materials. This research will lead to significant advances in advanced materials and adsorbent technology, downstream processing for the biotechnology industries, and understanding of highly specific affinity interactions used for difficult bioseparations. It will have important benefits for processes involving protein purification, such as bioplasma processing, as well as flow on effects to other applications of adsorbent technology such as food processing and water treatment. The new adsorbents will lead to reductions in the costs, energy usage and waste generation of Australian industries.Read moreRead less
Interfacial Studies of Nanoparticulate Dendrimers for Improved BioPharmaceutical Application. Dendrimers are a novel class of nanoparticles with exciting potential as pharmaceuticals for the prevention of major disease states, e.g. viral and cancer. A colloid and interfacial chemistry approach will be employed to develop an understanding of the mechanisms for the solution to cell transport processes and for optimisation of formulation strategies for delivery vehicles. Significant advances in t ....Interfacial Studies of Nanoparticulate Dendrimers for Improved BioPharmaceutical Application. Dendrimers are a novel class of nanoparticles with exciting potential as pharmaceuticals for the prevention of major disease states, e.g. viral and cancer. A colloid and interfacial chemistry approach will be employed to develop an understanding of the mechanisms for the solution to cell transport processes and for optimisation of formulation strategies for delivery vehicles. Significant advances in the development of novel pharmaceutical products will result, with significant social and economic benefits nationally and internationally.Read moreRead less
Multiplexed Molecular Reading of Protein Associations via Nanoscaled Devices. Current developments in Nanoscience and Nanotechnology hold many promises in terms of revolutionising our industrial base, transforming biology, medical science and practice. This project strives to achieve some of these goals by, for the first time, building and testing nano-scaled devices with the capability to rapidly ?read? information about complex protein associations. With the recent completion of the Human Ge ....Multiplexed Molecular Reading of Protein Associations via Nanoscaled Devices. Current developments in Nanoscience and Nanotechnology hold many promises in terms of revolutionising our industrial base, transforming biology, medical science and practice. This project strives to achieve some of these goals by, for the first time, building and testing nano-scaled devices with the capability to rapidly ?read? information about complex protein associations. With the recent completion of the Human Genome project, major opportunities exist to provide spectacular advances in human health care (eg, via novel diagnostics) provided that appropriate high-throughput biological reading devices can be developed. In developing such devices, this project also aims to catalyse the Australian Nanotechnology/Biotechnology industry.Read moreRead less