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Structural Characterisation of the Type IX Secretion System. The Type IX Secretion System present in diverse bacteria of veterinary, agricultural, environmental and industrial importance enables effector proteins to be secreted and attached to the cell surface where they contribute to disease pathogenesis or degrade biopolymers of commercial interest. This project aims to determine the structure and assembly mechanism of this complex secretion nanomachine comprising 15 different proteins using s ....Structural Characterisation of the Type IX Secretion System. The Type IX Secretion System present in diverse bacteria of veterinary, agricultural, environmental and industrial importance enables effector proteins to be secreted and attached to the cell surface where they contribute to disease pathogenesis or degrade biopolymers of commercial interest. This project aims to determine the structure and assembly mechanism of this complex secretion nanomachine comprising 15 different proteins using state of the art microscopy. Knowledge of the structure will greatly enhance our understanding of secretion mechanisms and our ability to both inhibit the system to treat disease in animals or manipulate the system for industrial applications providing future economic and environmental benefits to our nation.Read moreRead less
Novel Babesia proteins and their roles in the pathogenesis of tick fever. This project aims at gaining a deep understanding of the biology of Babesia parasites and how they cause tick fever in cattle. The project expects to discover novel parasite proteins involved in the development and persistence of tick fever and identify their functional role in infection. The main expected outcome is the discovery of parasite proteins that are critical for infection and pathogenesis of cattle tick fever. T ....Novel Babesia proteins and their roles in the pathogenesis of tick fever. This project aims at gaining a deep understanding of the biology of Babesia parasites and how they cause tick fever in cattle. The project expects to discover novel parasite proteins involved in the development and persistence of tick fever and identify their functional role in infection. The main expected outcome is the discovery of parasite proteins that are critical for infection and pathogenesis of cattle tick fever. The findings will contribute to the development of future novel vaccines to control tick fever, with significant economic benefits for the beef and dairy industries worldwide.Read moreRead less
Bacterial vesicles transport their bioactive cargo to the host nucleus. This project aims to investigate how bacterial membrane vesicles transport their cargo to the nucleus of cells and its impact on host cell functions. Bacteria use membrane vesicles as a means of communication with the host, but the full extent of their effects on host cells has yet to be fully elucidated. This project expects to generate new knowledge in the field using cutting-edge imaging and molecular biology approaches. ....Bacterial vesicles transport their bioactive cargo to the host nucleus. This project aims to investigate how bacterial membrane vesicles transport their cargo to the nucleus of cells and its impact on host cell functions. Bacteria use membrane vesicles as a means of communication with the host, but the full extent of their effects on host cells has yet to be fully elucidated. This project expects to generate new knowledge in the field using cutting-edge imaging and molecular biology approaches. The work should provide significant benefits, particularly towards the development of membrane vesicles in gene therapy, gene editing and other applications. Read moreRead less