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The effects of damage and repair of fungal DNA on animal and plant diseases. DNA damage and its repair are implicated in enhancing the ability of fungi to cause disease. These processes enable genomic changes that generate fungal strains better adapted to host colonisation. This project will identify factors that influence mutation, virulence and host adaptation in two model fungi that cause devastating diseases - a human pathogen, Cryptococcus neoformans, and a plant pathogen, Leptosphaeria mac ....The effects of damage and repair of fungal DNA on animal and plant diseases. DNA damage and its repair are implicated in enhancing the ability of fungi to cause disease. These processes enable genomic changes that generate fungal strains better adapted to host colonisation. This project will identify factors that influence mutation, virulence and host adaptation in two model fungi that cause devastating diseases - a human pathogen, Cryptococcus neoformans, and a plant pathogen, Leptosphaeria maculans. Since increases in global temperatures are expected to lead to emerging fungal diseases, understanding effects of damage and repair of fungal DNA on animal and plant diseases is key to designing disease control approaches.Read moreRead less
Investigating the intercellular trafficking of proteins and RNA and its relevance to neurodegenerative diseases. Alzheimer's and prion diseases are neurodegenerative disorders associated with protein misfolding. This project brings together similar features of these diseases using novel cell- and animal-based studies to develop a greater understanding of the molecular basis of these disorders.