The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Collision physics in lighting, fusion and astrophysical plasmas. The project will apply advanced fundamental science techniques to applications that have a high impact on the environment. These include improving energy efficiency of fluorescent lamps and development of new mercury-free designs and research in support of the international multi-billion dollar fusion energy program.
Electron, positron, and heavy-particle collisions with molecules. This project aims to develop a computational approach to collisions involving molecular targets with electrons, positrons and heavy particles. Recently, the approach to atomic collisions, the Convergent Close Coupling (CCC) method, has been extended and verified for positron, electron, and heavy particle collisions with the simplest molecular systems (molecular hydrogen and its ion). This project now aims to extend the CCC method ....Electron, positron, and heavy-particle collisions with molecules. This project aims to develop a computational approach to collisions involving molecular targets with electrons, positrons and heavy particles. Recently, the approach to atomic collisions, the Convergent Close Coupling (CCC) method, has been extended and verified for positron, electron, and heavy particle collisions with the simplest molecular systems (molecular hydrogen and its ion). This project now aims to extend the CCC method to study collisions with more complex molecules. Expected benefits include more accurate data for diagnostic tools such as Positron Emission Tomography, and potential advances in particle-based cancer therapy.Read moreRead less
Quantum collision theory for astrophysics, fusion energy and hadron therapy. The project intends to investigate collision processes involving charged particles interacting with complex atoms and molecules. Although the theory of electron, positron and ion collisions with simple atoms and molecules has advanced in recent years, the corresponding computational modelling is difficult due to the mix of the countably and uncountably infinite spectrum of the target, the long-range Coulomb potential, a ....Quantum collision theory for astrophysics, fusion energy and hadron therapy. The project intends to investigate collision processes involving charged particles interacting with complex atoms and molecules. Although the theory of electron, positron and ion collisions with simple atoms and molecules has advanced in recent years, the corresponding computational modelling is difficult due to the mix of the countably and uncountably infinite spectrum of the target, the long-range Coulomb potential, and the multicentre nature of the target and the rearrangement processes. These difficulties could be overcome using a convergent close-coupling method. This project plans to apply the method to complex quantum collision systems in diverse applications of current interest such as fusion energy, lighting, astrophysics, and cancer imaging and therapy.Read moreRead less
Mechanisms Underlying Growth, Lineage Commitment And Differentiation Of Liver Progenitor Cells
Funder
National Health and Medical Research Council
Funding Amount
$535,333.00
Summary
Liver disease is a serious health problem. Viral hepatitis, obesity and alcohol can result in end-stage liver disease. Organ transplant is the only treatment available. A widening gap between organ donations and recipients mandates alternative treatments are developed. Cell transplantation and artificial liver devices are alternatives which can use liver progenitor cells. We will investigate how factors grow and convert them into liver cells for treating liver disease patients.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Postviral Wheezing In Childhood: Disregulation Of Airway Tone?
Funder
National Health and Medical Research Council
Funding Amount
$577,040.00
Summary
Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. Ho ....Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. However, many infants who wheeze with viral infections, especially in the first year of life, do not develop allergies in later life, raising the possibility that they did not have the same type of asthma as those whose symptoms persist. This project will study the effects of viral infections on lung function to determine whether particular types of virus can have detrimental effects of lung function lasting for years. We will also examine whether the age at which the infection occurs and the severity of the infection influence the long-term outcome. The project involves studying infants during the recovery phase of respiratory viral infections, older children years after documented infections and experimental animal models that have been infected under controlled conditions. By determining whether respiratory viral infections can have long-term effects on lung function that can mimic asthma, we will advance our understanding of how asthma develops. In addition, specific treatment and preventative strategies could then be developed to prevent these long-term abnormalities, instead of relying on asthma medication (especially inhaled corticosteroids) as is the current practice. Preventative strategies could include encouraging the development of specific vaccines.Read moreRead less