The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Cooperative control of networked systems with constraints. This project aims to address the challenge of networked systems in deploying teams of robotic agents. Control of the networked system is extremely difficult due to real world constraints imposed on each agent. This project will focus on motion constraints, equipment/capability constraints, and spatial constraints. In addition to theoretical advances, the wider scientific community will benefit directly, because the control algorithms dev ....Cooperative control of networked systems with constraints. This project aims to address the challenge of networked systems in deploying teams of robotic agents. Control of the networked system is extremely difficult due to real world constraints imposed on each agent. This project will focus on motion constraints, equipment/capability constraints, and spatial constraints. In addition to theoretical advances, the wider scientific community will benefit directly, because the control algorithms developed are expected to allow straightforward deployment of robotic teams. There are myriad applications for cooperative robotic agents, ranging from surveillance, to environmental monitoring using underwater and aerial drone formations – with an array of benefits and impacts including economic, commercial and societal. The results are intended to ensure and cement Australia’s front-line position in the current technological revolution known as “Industry 4.0”.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100003
Funder
Australian Research Council
Funding Amount
$4,930,205.00
Summary
ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and devel ....ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and develop biofilm management strategies. Expected outcomes include new and enhanced collaborations that advance and translate knowledge to better manage biofouling. The significant benefits will include a generation of industry-focused researchers critical for growing Australia’s Defence industry.Read moreRead less
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
Control and Optimization of Distributed Multiagent Formations. The project aims to develop a conceptual framework and algorithms for handling multi-vehicle formation control. Formations of unmanned airborne vehicles are currently used by defence forces and swarms of micro-vehicles are beginning to find increasing use in defence and for civilian emergency response, largely for surveillance purposes. Vehicles must cooperate to achieve a global formation objective, while respecting constraints on s ....Control and Optimization of Distributed Multiagent Formations. The project aims to develop a conceptual framework and algorithms for handling multi-vehicle formation control. Formations of unmanned airborne vehicles are currently used by defence forces and swarms of micro-vehicles are beginning to find increasing use in defence and for civilian emergency response, largely for surveillance purposes. Vehicles must cooperate to achieve a global formation objective, while respecting constraints on sensors, energy, and general mechanical limitations. The project aims to resolve the challenges of deciding what a single vehicle should observe, what and to where it should communicate, and how it should move in relation to what it sees. The conceptual framework developed may also be relevant in guiding future defence acquisitions and civilian applications.Read moreRead less
What drives parasite spread through social networks: lessons from lizards. Australia's biodiversity is continually threatened by new epidemics of local and foreign diseases and parasites. This project will enhance our understanding of how these diseases spread, allowing more effective controls to be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
Silicon: a novel solution to reduce water use and pest damage in wheat. The project aims to improve Australian wheat production by increasing drought resilience and reducing reliance on pesticides. This is achieved by incorporating amorphous silicon (Si), an abundant national resource. Si uptake by wheat has been proven to alleviate stress from drought and pests, but mechanisms and agronomic feasibility remain to be fully assessed. The project will deliver a mechanistic understanding of how Si a ....Silicon: a novel solution to reduce water use and pest damage in wheat. The project aims to improve Australian wheat production by increasing drought resilience and reducing reliance on pesticides. This is achieved by incorporating amorphous silicon (Si), an abundant national resource. Si uptake by wheat has been proven to alleviate stress from drought and pests, but mechanisms and agronomic feasibility remain to be fully assessed. The project will deliver a mechanistic understanding of how Si alleviates stress in wheat, from gene to farm scale, providing cost-benefit analysis and a best–practice toolbox for implementation by farmers. Outcomes are anticipated to provide a cheaper and more environmentally sustainable solution to issues of water scarcity and yield losses to pests in Australia’s leading crop.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100030
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub in Intelligent Robotic Systems for Real-Time Asset Management. This hub aims to transform the way assets and infrastructure are managed by developing new capabilities for intelligent robotic systems for inspection, monitoring, and maintenance. The hub expects to generate new knowledge in robotics and associated fields including sensing, planning, data processing, and machine learning using interdisciplinary approaches and tight collaboration between academia and industry. The ex ....ARC Research Hub in Intelligent Robotic Systems for Real-Time Asset Management. This hub aims to transform the way assets and infrastructure are managed by developing new capabilities for intelligent robotic systems for inspection, monitoring, and maintenance. The hub expects to generate new knowledge in robotics and associated fields including sensing, planning, data processing, and machine learning using interdisciplinary approaches and tight collaboration between academia and industry. The expected outcomes are robots with the ability to autonomously collect data for integration into a digital twin that provides a real-time representation of the true state of a physical asset. The benefits include both improved asset management and establishing Australia as a leading manufacturer of advanced robotic systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100155
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
An Ultra-wideband Radio Receiver for the Parkes 64-metre Radio Telescope. An ultra-wideband radio receiver for the Parkes 64-metre radio telescope: This project aims to construct a state-of-the-art ultra-wide-band receiver and signal processing system for the Parkes 64-metre radio telescope. The receiver will operate across the entire 700 megahertz to four gigahertz band with outstanding sensitivity and polarimetric performance, providing a unique capability for high-time-resolution wide-bandwid ....An Ultra-wideband Radio Receiver for the Parkes 64-metre Radio Telescope. An ultra-wideband radio receiver for the Parkes 64-metre radio telescope: This project aims to construct a state-of-the-art ultra-wide-band receiver and signal processing system for the Parkes 64-metre radio telescope. The receiver will operate across the entire 700 megahertz to four gigahertz band with outstanding sensitivity and polarimetric performance, providing a unique capability for high-time-resolution wide-bandwidth astronomy. It is expected to deliver enhanced science outcomes for a wide range of projects and greatly improve the telescope's operational efficiency, extending its lifetime into the Square Kilometre Array era. Key science projects include tests of theories of relativistic gravitation, including the search for gravitational waves, probing neutron star interiors and investigations of the magnetic structure of our galaxy.Read moreRead less