Investigation Of Early Cell Surface Rearrangements Mediating Adequate TCR-pMHC Engagement
Funder
National Health and Medical Research Council
Funding Amount
$303,708.00
Summary
This project aims to use advanced cell imaging techniques to view precise interactions that occur between cells as our immune system attacks and destroys infected cells. The techniques to be employed are highly advanced and involve cutting edge science. Essentially these techniques allow the production of movies of the body's immune system in action. Determining these interactions in such detail is important for understanding the body’s ability to fight infection.
The Researching Editing and Publication of Historical Records of Australia. These will be two fold: first in continuing and completing the original Historical Records of Australia Series originally supported and promoted by the Commonwealth Parliamentary Library, shortly after Federation, thus using a Federation Fellowship to complete a great original Federation project; second by providing in edited research form as as described above, the vital historical documentation of historical proce ....The Researching Editing and Publication of Historical Records of Australia. These will be two fold: first in continuing and completing the original Historical Records of Australia Series originally supported and promoted by the Commonwealth Parliamentary Library, shortly after Federation, thus using a Federation Fellowship to complete a great original Federation project; second by providing in edited research form as as described above, the vital historical documentation of historical processes continuing in this country , especially in relation to the indigenous peoples of Australia, the governance of the states, and matters of crime, punishment and emigration which were at the heart of the political debates and developing policies of the era and which are matters of significance in present AustraliaRead moreRead less
Interactive and scalable media over software defined networks. A novel API and associated algorithms will be developed to exploit the emerging technology of software defined networks (SDN) for improving the efficiency and responsiveness of interactive media browsing applications. The approach applies to conventional streaming video as well as more interactive services based on scalable media compression and communication technology, notably JPIP (IS15444-9) video. Recent advances in motion codin ....Interactive and scalable media over software defined networks. A novel API and associated algorithms will be developed to exploit the emerging technology of software defined networks (SDN) for improving the efficiency and responsiveness of interactive media browsing applications. The approach applies to conventional streaming video as well as more interactive services based on scalable media compression and communication technology, notably JPIP (IS15444-9) video. Recent advances in motion coding will be combined with new spatio-temporal transforms to develop an efficient inter-frame extension to the JPEG 2000 standard that is fully compatible with JPIP. Each of these innovations is important in its own right, but together they will facilitate a highly compelling interactive media browsing experience.Read moreRead less
Object-based motion estimation for highly efficient streaming video. This project aims to develop motion and shape estimation tools that allow video content to be predicted at any point in time using frame data that is available at other points in time. Applications of this include video coding, frame synthesis for temporal re-sampling. The project expects to develop algorithms for jointly estimating compact motion and shape descriptions of video content. These descriptions will allow quality re ....Object-based motion estimation for highly efficient streaming video. This project aims to develop motion and shape estimation tools that allow video content to be predicted at any point in time using frame data that is available at other points in time. Applications of this include video coding, frame synthesis for temporal re-sampling. The project expects to develop algorithms for jointly estimating compact motion and shape descriptions of video content. These descriptions will allow quality refinement by progressively adding spatial and temporal detail. It is expected that these compact descriptions will lead to significantly more flexible and efficient transmission of video content over modern communications networks.Read moreRead less
Robert Frank: Experimentation Across Film and Photography in Post-War America. A study of Frank's career will establish critical models that can be applied to the work of Australian artists and filmmakers – especially those whose personal histories are linked to the waves of immigration that occurred during the '50s and '60s. The publication of a monograph, journal articles, interviews, a DVD and the staging of a retrospective will increase public awareness not only of Frank's work but also the ....Robert Frank: Experimentation Across Film and Photography in Post-War America. A study of Frank's career will establish critical models that can be applied to the work of Australian artists and filmmakers – especially those whose personal histories are linked to the waves of immigration that occurred during the '50s and '60s. The publication of a monograph, journal articles, interviews, a DVD and the staging of a retrospective will increase public awareness not only of Frank's work but also the work of those he has influenced. By including an overseas classroom element, this project also provides the opportunity to showcase the quality of Australian film research to high-calibre US students. This is vital to maintaining Australia's international reputation as a provider of film and media research.Read moreRead less
Sierra Leone and Australia: a case of the vanishing twin. By considering the settlement of Australia as a process within an interconnected global empire the project will increase understanding of our beginnings and inject Australian experience into international scholarship. It will increase our understanding of Africa, 'the world's largest unstable region', which is peculiarly absent from the Australian consciousness. Paul Lovejoy, our international PI, is a world leader in African history, and ....Sierra Leone and Australia: a case of the vanishing twin. By considering the settlement of Australia as a process within an interconnected global empire the project will increase understanding of our beginnings and inject Australian experience into international scholarship. It will increase our understanding of Africa, 'the world's largest unstable region', which is peculiarly absent from the Australian consciousness. Paul Lovejoy, our international PI, is a world leader in African history, and his involvement in this initiative will focus the attention of the international African historical community on Australia. The project will also provide an inclusive historical context to assist the incorporation of a large refugee cohort from Sierra Leone.Read moreRead less
Development Of A New Surgical-guidance Tool For Intra-operative Tumour Margin Assessment In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$557,982.00
Summary
One third of breast cancer patients undergoing breast conserving surgery have insufficient tissue removed, resulting in an increased risk of recurrence. We have developed a high resolution optical imaging probe with the potential to detect small areas of cancer. It could be used to help guide the surgeon to remove all cancerous tissue from the patient. This grant will allow us to develop the probe to a stage that it can be used during surgery, and perform the world’s first clinical scans.
The Monetisation of Children in the Digital Games Industry. This project aims to understand the monetisation of children in the digital games industry. It will employ innovative studies of children’s experiences in freemium games; parental attitudes and strategies; participatory research with game developers; and an examination of the platform and regulatory environment that shapes game monetisation. Expected outcomes include guidelines and recommendations for parents seeking to negotiate childr ....The Monetisation of Children in the Digital Games Industry. This project aims to understand the monetisation of children in the digital games industry. It will employ innovative studies of children’s experiences in freemium games; parental attitudes and strategies; participatory research with game developers; and an examination of the platform and regulatory environment that shapes game monetisation. Expected outcomes include guidelines and recommendations for parents seeking to negotiate children’s digital play; new ethical frameworks for the design and implementation of digital games for children; and actionable advice for policymakers and practitioners. This will bring significant benefits to Australian children, parents and game developers via improvements to the design of games for children.Read moreRead less
Development Of Microscope-in-a-needle Devices For Improved Clinical Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$327,746.00
Summary
We have developed a new high-resolution optical imaging technology. The unique aspect of our research has been to redesign the imaging probe, miniaturising it to a few hundred microns in diameter, and encase it in a hypodermic needle – a ‘microscope-in-a-needle’. We are developing specific imaging probes to aid in the assessment of lung disease; the diagnosis of liver disease; and integrated into a brain biopsy needle to enable safer brain biopsies.