A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.
Discovery Early Career Researcher Award - Grant ID: DE240101275
Funder
Australian Research Council
Funding Amount
$382,440.00
Summary
Paying and playing: Assessing and regulating digital games-as-a-service . The digital games industry has turned to a service-based business model reliant on the generation of continuous user revenue. This project assesses the implications of service-based monetisation for how games are designed, consumed, and regulated, focusing on three controversial, yet insufficiently understood monetisation strategies: advertising, in-game transactions, and blockchain-based play. While promising benefit for ....Paying and playing: Assessing and regulating digital games-as-a-service . The digital games industry has turned to a service-based business model reliant on the generation of continuous user revenue. This project assesses the implications of service-based monetisation for how games are designed, consumed, and regulated, focusing on three controversial, yet insufficiently understood monetisation strategies: advertising, in-game transactions, and blockchain-based play. While promising benefit for consumers and industry, these monetisation strategies carry the potential for risks like surveillance, harmful advertising, and predatory design. Discoveries from this project will help policymakers, industry, and consumers regulate, design, and use games featuring service-based monetisation in effective and ethical ways.Read moreRead less
Internet-distributed television: cultural, industrial and policy dynamics. This project aims to investigate the impact of global subscription video-on-demand platforms on national television markets. The rise of subscription video streaming has created significant challenges for Australian and international broadcast, media and cultural policy frameworks, which are struggling to keep up with audience viewing practices. This project will provide a comparative analysis of how governments are respo ....Internet-distributed television: cultural, industrial and policy dynamics. This project aims to investigate the impact of global subscription video-on-demand platforms on national television markets. The rise of subscription video streaming has created significant challenges for Australian and international broadcast, media and cultural policy frameworks, which are struggling to keep up with audience viewing practices. This project will provide a comparative analysis of how governments are responding and investigating the implications for debates about local content, local screen production, and media diversity. The project will provide an analysis of original production and programming strategies to identify new forms of trans-national media flow. The project will advance an understanding of media globalisation and provide media regulators options and opportunities for a convergent media policy environment.Read moreRead less
Artistic Practice in Australian Videogame Development. The game industry is the largest cultural industry in the world. Its economic growth relies in part on the artistic innovations of non-commercial developers and communities operating beyond the industry’s purview. Policymakers and researchers alike struggle to account for the cultural contexts and creative origins of game development. This project conceptualises and empirically investigates ‘artist-gamemaking’ to generate new knowledge on th ....Artistic Practice in Australian Videogame Development. The game industry is the largest cultural industry in the world. Its economic growth relies in part on the artistic innovations of non-commercial developers and communities operating beyond the industry’s purview. Policymakers and researchers alike struggle to account for the cultural contexts and creative origins of game development. This project conceptualises and empirically investigates ‘artist-gamemaking’ to generate new knowledge on the ambitions, techniques and histories of Australia’s game industry. It develops resources that will enable cultural institutions to better support them. This research is important as it articulates the cultural and economic value of a vital site of creative practice in contemporary Australia.Read moreRead less
Regional development of audiovisual industries in the digital era: Prospects for the Northern Rivers region of NSW. This project explores drivers and impediments within audiovisualindustries in the global digital era that impact on the industry's develoment in non-metropolitan regions. The project uses the Northern Rivers region of NSW as the major case study. It will evaluate opportunities arising from technological, economic and societal changes associated with the digital media era and iden ....Regional development of audiovisual industries in the digital era: Prospects for the Northern Rivers region of NSW. This project explores drivers and impediments within audiovisualindustries in the global digital era that impact on the industry's develoment in non-metropolitan regions. The project uses the Northern Rivers region of NSW as the major case study. It will evaluate opportunities arising from technological, economic and societal changes associated with the digital media era and identify relevant public policy influences. It will facilitate the development of tools and strategies for regional development practitioners and entrepreneurs in the 'Creative Industries' sector. It will highlight policy instruments for governments wanting to take advantage of benefits from the 'new' services and knowledge-based economies.Read moreRead less
Informal economies and audiovisual industries: histories, dynamics, legal and policy responses. This project will uncover new information about the connections between formal and informal media industries. It will generate valuable new knowledge about innovation in contemporary media, and will contribute to policy discussions in the lead-up to the National Broadband Network.
Short Sequence Representation Learning with Limited Supervision . Predicting events based on short text and video data is widely found in real-world applications such as online crime detection, cyber-attack identification, and public security protection. However, to develop such an effective prediction model is very difficult due to the problems such as limited supervision, heterogeneous multiple sources, and missing and low-quality data. This project is to tackle these challenges. Expected outc ....Short Sequence Representation Learning with Limited Supervision . Predicting events based on short text and video data is widely found in real-world applications such as online crime detection, cyber-attack identification, and public security protection. However, to develop such an effective prediction model is very difficult due to the problems such as limited supervision, heterogeneous multiple sources, and missing and low-quality data. This project is to tackle these challenges. Expected outcome of this project will lay a theoretical foundation for effective short sequence representation learning and build next-generation intelligent systems. This should benefit our society and economy through the applications of multimodality-integrated video technologies for cybersecurity and public safety. Read moreRead less
The new services industry model: Implications for audio-visual media. This project examines important current changes in the understanding of audio-visual media. Governments, academics, industry players and international organisations have developed a new 'services industry model' to map future directions and policies for audio-visual industries. However little attention has been given to how this model may apply to the complex cultural and social role of audio-visual media. This project aims to ....The new services industry model: Implications for audio-visual media. This project examines important current changes in the understanding of audio-visual media. Governments, academics, industry players and international organisations have developed a new 'services industry model' to map future directions and policies for audio-visual industries. However little attention has been given to how this model may apply to the complex cultural and social role of audio-visual media. This project aims to fill this gap through a series of substantial publications on four key problems: the conversion to digital transmission platforms; public broadcasting and its future role; international policy dynamics, and the re-evaluation of longstanding domestic social and cultural policy objectives.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100313
Funder
Australian Research Council
Funding Amount
$373,536.00
Summary
International Transformations in Children’s Television 2013-18. This project intends to analyse key trends in the production and distribution of contemporary children’s television. Contemporary Australian television is produced and distributed through complex processes in a globalised media environment characterised by convergence and multi-platform delivery. This project plans to map the shape and scale of rapidly evolving production territories and markets for children’s television opened up b ....International Transformations in Children’s Television 2013-18. This project intends to analyse key trends in the production and distribution of contemporary children’s television. Contemporary Australian television is produced and distributed through complex processes in a globalised media environment characterised by convergence and multi-platform delivery. This project plans to map the shape and scale of rapidly evolving production territories and markets for children’s television opened up by media globalisation, and explore their economic and cultural impact on television made for the child audience. Its findings may reveal the implications of new global settlements in children’s television for media industries, production practices and policy settlements in both the national and the transnational space.Read moreRead less
Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms t ....Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.Read moreRead less