Three percent of children born in Australia are from IVF. It is typical in IVF to replace 2 or more embryos in order to attain an acceptable pregnancy rate. However, twin pregnancies are common as a result, with 25% of all twins coming from IVF. Twins represent a real medical issue for mother and infants. Therefore, this research will use new highly innovative technologies to determine the health of an individual embryo in the culture dish prior to transfer, making the selection and transfer of ....Three percent of children born in Australia are from IVF. It is typical in IVF to replace 2 or more embryos in order to attain an acceptable pregnancy rate. However, twin pregnancies are common as a result, with 25% of all twins coming from IVF. Twins represent a real medical issue for mother and infants. Therefore, this research will use new highly innovative technologies to determine the health of an individual embryo in the culture dish prior to transfer, making the selection and transfer of an individual embryo a reality.Read moreRead less
Manipulating Ovarian Follicle - Oocyte Communication To Control Reproductive Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$567,424.00
Summary
Ovarian follicles provide the environment supporting oocyte (egg) development. Communication between cells of the follicle and oocytes modulate this environment. We discovered new cell surface molecules that receive the signals from the oocyte and we identified a class of drug compounds that can modulate this signalling. This discovery offers a unique potential to therapeutically intervene in this signalling process and both improve infertility therapies and develop new non-steroidal contracepti ....Ovarian follicles provide the environment supporting oocyte (egg) development. Communication between cells of the follicle and oocytes modulate this environment. We discovered new cell surface molecules that receive the signals from the oocyte and we identified a class of drug compounds that can modulate this signalling. This discovery offers a unique potential to therapeutically intervene in this signalling process and both improve infertility therapies and develop new non-steroidal contraceptives.Read moreRead less