The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Defining The Roles Of The Chemotactic Receptor EBI2 For The Regulation Of Leukocyte Migration And The Generation Of Immunity
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The proposed study aims at improving our understanding of the role of the immune cell receptor Epstein-Barr virus-induced gene 2 (EBI2) in guiding the movement of white blood cells during immune responses. The project will investigate the function of EBI2 in the control of infectious diseases and its regulation on human immune cells. These insights have the potential to create new therapeutic approaches to treat human autoimmune and inflammatory diseases and improve vaccine design.
Coordinating Leukocyte Migration And Interaction During Immune Responses: The Multiple And Central Roles Of The Orphan G Protein Coupled Receptor EBI2
Funder
National Health and Medical Research Council
Funding Amount
$512,716.00
Summary
The ability of the immune system to fight infections relies on the capacity of immune cells to navigate within the body. This study aims at understanding the role of the immune cell receptor Epstein-Barr virus-induced gene 2 (EBI2) in guiding the movement and the interaction of the different types of white blood cells during immune responses. These insights will add to our understanding of immune cell migration thereby offering new therapeutic approaches to improve or control immune responses.
Biochemistry And Cell Biology Of Antigen Presentation And T Cell Activation
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
José Villadangos studies the cells and molecules involved in Antigen Presentation. This phenomenon consists of the detection, capture and display of microbe fragments on the surface of Antigen Presenting Cells (APC) for recognition by T cells. This initiates an immune response that culminates in the deployment of cells and molecules armed to fight the infection. His research may lead to development of more effective vaccines and prevention of autoimmunity, allergy and transplant rejection.
Characterisation Of The Antigen Cross-presentation Pathway In Dendritic Cells
Funder
National Health and Medical Research Council
Funding Amount
$593,888.00
Summary
T cells and Dendritic Cells (DC) are important components of the immune system. DC detect bacterial and viral infections and activate T cells to fight those infections. Our goal is to understand how DC communicate with T cells. This knowledge will allow us to develop new vaccines and to interfere with the mechanisms that enable infectious agents to escape detection.
Trafficking inside the cell for effective immunity. This project aims to investigate how cargo is trafficked to the right destination inside cells. The project will investigate the trafficking routes and the critical machinery required. This project is expected to generate fundamental new knowledge in the areas of cell biology and immunology. Expected outcomes of this Project include scholarly publications and highly-trained personnel in cell biology and immunology. This project will provide sig ....Trafficking inside the cell for effective immunity. This project aims to investigate how cargo is trafficked to the right destination inside cells. The project will investigate the trafficking routes and the critical machinery required. This project is expected to generate fundamental new knowledge in the areas of cell biology and immunology. Expected outcomes of this Project include scholarly publications and highly-trained personnel in cell biology and immunology. This project will provide significant benefits such as advances to fundamental knowledge, training for higher research degree students, opportunities for the biotechnology sector and strengthened international (research collaborations.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101626
Funder
Australian Research Council
Funding Amount
$394,179.00
Summary
Flotillin link membrane microdomains to signalling endosome during T cell activation. This project aims to determine the mechanisms that connect signalling microdomains at the cell surface to intracellular signalling endosomes to regulate T cell activation. A T cell immune response begins with the reorganisation of the plasma membrane to yield two-dimensional signalling microdomains that must be connected to the three-dimensional microarchitecture of the endocytic matrix for full T cell activati ....Flotillin link membrane microdomains to signalling endosome during T cell activation. This project aims to determine the mechanisms that connect signalling microdomains at the cell surface to intracellular signalling endosomes to regulate T cell activation. A T cell immune response begins with the reorganisation of the plasma membrane to yield two-dimensional signalling microdomains that must be connected to the three-dimensional microarchitecture of the endocytic matrix for full T cell activation. This project hypothesises that Flotillin form distinct signalling microdomains in the plasma membrane that internalise to constitute an independent endocytic pathway. Using single-molecule and ultra-fast fluorescence imaging, the project will demonstrate that Flotillin represent a unique two-dimensional to three-dimensional regulatory mechanism for T cell signalling.Read moreRead less
Novel tools and nanotechnology to navigate intracellular trafficking. This project aims to investigate how material accesses different compartments inside cells, also known as trafficking. Using immunology, cell biology and nanotechnology, the project will manipulate intracellular trafficking to achieve specific cellular functions. Outcomes will also form the basis of intellectual property development for new products by Australian biotechnology companies. These products will improve veterinary ....Novel tools and nanotechnology to navigate intracellular trafficking. This project aims to investigate how material accesses different compartments inside cells, also known as trafficking. Using immunology, cell biology and nanotechnology, the project will manipulate intracellular trafficking to achieve specific cellular functions. Outcomes will also form the basis of intellectual property development for new products by Australian biotechnology companies. These products will improve veterinary and human health services, leading to increased productivity.Read moreRead less