NCE Based Strategy For Nuclear Reprogramming And Regenerative Medicine
Funder
National Health and Medical Research Council
Summary
Induced pluripotent stem cells (iPSCs) can be made by reprogramming adult cells. These cells can become any cell type in the human body. We can now create patient specific cells that may restore function in patients and not be rejected by their immune system. However, current methods for making iPSCs are slow, inefficient and have some safety concerns. This project aims to overcome these issues by using new chemical entities to reprogram cells that may be used for tissue repair and regeneration.
Development Of Targeted Therapies To Reverse The Effects Of Ageing And Disease On Wound Healing And Tissue Generation
Funder
National Health and Medical Research Council
Funding Amount
$391,228.00
Summary
Despite success with the production of new tissues and organs in laboratory animals, tissue engineering in humans remains elusive. Emerging evidence suggests that ageing and diseases such as diabetes can adversely affect human stem cell regenerative capacity. Characterizing the effects of ageing and disease on stem cells during tissue generation is the first step in reversing these effects, paving the way for the production of new tissues and organs for use in human clinical trials.
Smart Hybrid Material For Cartilage Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Tissue engineering is a promising approach to repair damaged/degenerated cartilage caused by various diseases or injuries. Because of its limited capacity for self repair cartilage becomes a constriant to normal everyday life once degenerated. This project aims to develop composite polymers for cartilage repair. The potential of this newly developed material for cartilage tissue engineering will be investigated through the material and biological characterisation techniques.