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Local Sleep In The Awake Brain: An Underlying Cause Of Neurobehavioural Deficits In Sleep Apnea?
Funder
National Health and Medical Research Council
Funding Amount
$582,330.00
Summary
Obstructive sleep apnea (OSA) is a common sleep disorder which significantly impacts daytime functioning leading to excessive sleepiness, and problems with attention and thinking. Currently, the causes for cognitive impairment in OSA (including attentional lapses and performance deficits) are poorly understood. In the awake state, groups of neurons can briefly go “offline” as they do in sleep. These periods of “local sleep” may explain impaired task performance in OSA.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
Advanced metallisation for III-V Photovoltaic Solar Power Systems. This project aims to augment the overall electrical efficiency of concentrator photovoltaic solar systems that provide large-scale generation of cheap, clean electricity. Existing concentrator solar cells are highly efficient (>40%) but their performance is hampered by thick front-metal contacts that shade the cell. The project is expected to develop a new concentrator solar cell metalisation and insulation technology. The benefi ....Advanced metallisation for III-V Photovoltaic Solar Power Systems. This project aims to augment the overall electrical efficiency of concentrator photovoltaic solar systems that provide large-scale generation of cheap, clean electricity. Existing concentrator solar cells are highly efficient (>40%) but their performance is hampered by thick front-metal contacts that shade the cell. The project is expected to develop a new concentrator solar cell metalisation and insulation technology. The benefit of the project will be a direct increase in the system efficiency and simplified manufacturing of the concentrator solar receiver, which in turn reduces the cost of the concentrator power plant constructed by our Australian project partner RayGen Resources Pty Ltd.Read moreRead less
The Role Of Chemokines In Establishing HIV Latency
Funder
National Health and Medical Research Council
Funding Amount
$372,049.00
Summary
Although antiviral therapy is effective in controlling HIV, therapy must be continued life-long because the virus cannot be cleared from long lived infected CD4+ T cells that are silently or latently infected. In this proposal we will explore the mechanism of how HIV can enter these resting CD4+ T-cells and establish long lived latent infection. Understanding this process may potentially lead to new strategies to cure HIV infection.
Discovery Early Career Researcher Award - Grant ID: DE230100637
Funder
Australian Research Council
Funding Amount
$428,154.00
Summary
An integrated electrolyser for CO2 conversion from capture media. This project aims to develop an efficient electrochemical method to convert carbon dioxide (CO2) to valuable chemicals. It expects to displace the energy-costly step of its upstream CO2 capture process. The key novelty is the use of flow-through electrodes and optimal solvents to promote CO2 conversion at high rates. Expected outcomes include enhanced efficiency of CO2 sequestration, and new techniques to develop electrodes with w ....An integrated electrolyser for CO2 conversion from capture media. This project aims to develop an efficient electrochemical method to convert carbon dioxide (CO2) to valuable chemicals. It expects to displace the energy-costly step of its upstream CO2 capture process. The key novelty is the use of flow-through electrodes and optimal solvents to promote CO2 conversion at high rates. Expected outcomes include enhanced efficiency of CO2 sequestration, and new techniques to develop electrodes with well-controlled local reaction environments, which are essential for electrochemical energy conversion and storage. This will benefit Australia's environment and industries such as cement and aluminium manufacturing in managing carbon emissions, and accelerate Australia’s transition to a carbon-neutral economy.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100022
Funder
Australian Research Council
Funding Amount
$4,420,408.00
Summary
ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess a ....ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess and optimise the healing process. In addition, the Centre will produce data for use in deriving the next-generation of implants, giving rise to improved health outcomes, economic benefits, and a skilled workforce able to advance and perpetuate this important field.Read moreRead less
A new defect-control approach for mismatched heteroepitaxy semiconductors. This project aims to develop a new defect-control approach for silicon-germanium heteroepitaxial semiconductor systems to provide a route for high-throughput, low-cost, high-efficiency silicon tandem solar cells. Mismatched heteroepitaxy of semiconductors is of considerable interest for fabricating novel devices. However, the use of highly-mismatched heteroepitaxial semiconductors has been limited due to the high densitie ....A new defect-control approach for mismatched heteroepitaxy semiconductors. This project aims to develop a new defect-control approach for silicon-germanium heteroepitaxial semiconductor systems to provide a route for high-throughput, low-cost, high-efficiency silicon tandem solar cells. Mismatched heteroepitaxy of semiconductors is of considerable interest for fabricating novel devices. However, the use of highly-mismatched heteroepitaxial semiconductors has been limited due to the high densities of crystal defects which degrade the performance of both majority and minority carrier devices. This project aims to develop a new defect-control approach for heteroepitaxial semiconductors by continuous wavelength diode laser processing. With heteroepitaxial silicon-germanium as an example, the project will investigate the mechanism underlying defect-cleaning, optimised designs for best performance, and designs for high-efficiency tandem solar cells.Read moreRead less