Improving Endothelial Dysfunction In Diabetes-associated Vascular Diseases With Nrf2 Activators
Funder
National Health and Medical Research Council
Funding Amount
$340,039.00
Summary
Diabetic patients have a greater risk of developing cardiovascular diseases as compared to the general population. This is largely attributed to the impact the diabetic environment has on the endothelium (inner layer of the blood vessel). Indeed, clinical studies have shown that impaired endothelial function occurs prior to the development of cardiovascular diseases. Hence, we propose to study a novel way to improve endothelial function by limiting oxidative stress and inflammatory pathways.
Oxidative Stress, Heparan Sulfates And Endothelial Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$450,390.00
Summary
During vascular disease endothelial cells that line the blood lumen are dysfunctional. Growing evidence indicates a role for a protein that the immune system normally uses to destroy infectious agents. This protein accumulates in diseased blood vessels next to endothelial cells. This project will study how this protein causes endothelial dysfunction and test the ability of novel agents to remove this protein from diseased blood vessels to improve endothelial function.
Are Novel Nitric Oxide Mimetics Protective In Vascular Disease?
Funder
National Health and Medical Research Council
Funding Amount
$634,044.00
Summary
Nitric oxide (NO) is a biologically active gas which controls blood flow and blood pressure. New drugs which mimic the effects of NO show promise in the treatment of cardiovascular disease. This study investigates the ability of NO mimetics to protect blood vessels in disease, by limiting the production of toxic molecules, improving blood flow and preventing blood clot formation. The information gained may lead to the development of new therapies for blood vessel diseases such as stroke.
Pharmacological Effects Of Oral L-citrulline And Tetrahydrobiopterin In Patients With Peripheral Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$322,283.00
Summary
Citrulline, named after citrullus vulgaris, the watermelon, is a precursor of arginine. Arginine is converted to protective nitric oxide (NO), which is decreased in cardiovascular diseases (CVD). Although arginine supplementation can increase NO availability and improve vascular function it is hampered by a low availability. In contrast, Citrulline is highly available and converted to Arginine. Therefore, this project will explore the therapeutic effects of Citrulline in patients with CVD.
The health benefits of consuming fruits and vegetables can in part be attributed to their high content of polyphenolic compounds such as flavonoids. These substances can improve functioning of blood vessels and have the potential to reduce the risk of heart disease. This project will examine one of the most common flavonoids in the diet to try and understand how it works and better understand the protective effects.