Microvascular Complications Of Diabetes - Potential Role Of Regenerative Therapies
Funder
National Health and Medical Research Council
Funding Amount
$32,003.00
Summary
The global burden of diabetes is projected to reach more than 366 million by 2025. According to the AusDiab 2005 study, each year 0.8% of Australians develop diabetes. Diabetes is the leading cause of end-stage kidney disease in Australia. Current treatments slow damage to the kidney, but do not reverse kidney damage. We will explore the potential for adult progenitor cells (endothelial progenitor cells) to reverse damage to the kidney and restore its function.
Role Of Microparticles In Cardiac Ischemia Reperfusion Injury
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Interventional cardiology has reduced the mortality rate associated with heart attack, unfortunately the prevalence of heart failure has subsequently increased, caused in part by reperfusion injury of previously occluded vessels. We aim to identify novel insights into the pathogenesis of IR injury in the heart, as well as the development of new approaches to prevent cardiac damage during cardiac surgery, transplantation, post-angioplasty and coronary artery stenting.
Hypertension Induced Inflammation In The Endothelium: The Signalling Pathways Involved
Funder
National Health and Medical Research Council
Funding Amount
$58,313.00
Summary
Patients with high blood pressure are at an increased risk of heart attack and stroke in western societies. It appears that increased pressure induces an inflammation response which leads to the development of atherosclerosis. The aim of this project is to understand the vascular inflammatory mechanisms induced by high blood pressure with the view to prevent blood pressure-related complications such as atherosclerosis.