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Characterisation Of MiRNAs That Regulate Vascular Leakage.
Funder
National Health and Medical Research Council
Funding Amount
$167,493.00
Summary
Vascular permeability or leak is a major problem in diseases such as cancer and in cardiovascular diseases . MicroRNAs (miRNAs) are small control genes that influence dveleopment and disease. We have identified a miRNA cluster in endothelial cells, the cells that line the blood vessels, that is important in the control of vascular leak. This project is focused on understanding the impact of these miRNAs in disease.
Vascular Targeting Combined With Radiosurgery In An Arteriovenous Malformation Rat Model
Funder
National Health and Medical Research Council
Funding Amount
$102,345.00
Summary
Cerebral arteriovenous malformations are an important cause of stroke and brain bleeds. In many patients such a stroke can result in severe disability or death. Current management involves a combination of surgery, radiation therapy and endovascular treatments and carry a high risk of complications. This research project suggests a new form of treatment whereby irradiating the vascular malformation a medication could be administered to cause targeted clotting of the malformation.
Mechanisms Of Vascular Dysfunction During Acute And Chronic Hyperglycemia
Funder
National Health and Medical Research Council
Funding Amount
$56,700.00
Summary
Increased consumption of sugary drinks has contributed to an epidemic of obesity and diabetes and consequently cardiovascular disease. For the first time in living memory, this may well lead to declining life-expectancy. My research will examine both the short and long-term impact of sugary drinks on vital blood vessel function. In the process it will develop better methods to monitor blood vessel function and inform public health policy on sugary drinks and preventing cardiovascular disease.
Examining The Role Of Extracellular Myeloperoxidase In The Pathogenesis, Identification And Treatment Of High-risk Unstable And Ruptured Atherosclerotic Plaque
Funder
National Health and Medical Research Council
Funding Amount
$103,356.00
Summary
Vascular inflammation has emerged as a key driver and therapeutic target for stroke and heart attack. Existing diagnostic techniques and treatments do not target inflammation so that residual inflammatory risk remains. There is a need to identify patients with active inflammation who may benefit from treatment. Myeloperoxidase is an inflammatory enzyme abundant in plaque at risk of rupture and subsequent stroke or heart attack and presents as a potential diagnostic tool and therapeutic target.
Optimising Human Vascularisation And Liver Tissue Engineering Models To Develop Functional Bio-artificial Human Liver Tissue
Funder
National Health and Medical Research Council
Funding Amount
$124,761.00
Summary
This project aims to grow human blood vessels and liver cells derived from human stem cells within a supporting scaffold to generate a “liver in a dish”. Transplantation involves connecting blood vessels in this structure to those of the recipient. This should restore function in mice with human-like liver disease, thereby demonstrating potential of this technology to be developed as an alternative to liver transplantation.
Feasibility, Safety, Adherence, And Efficacy For High Intensity Interval Training In A Hospital-Initiated Rehabilitation Program For Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$75,779.00
Summary
This project aims to investigate if high intensity interval training can be successfully integrated into a hospital-based cardiac rehabilitation program as a practical and safe alternative to the usual care exercise protocol (moderate intensity continuous training). We expect high intensity interval training will be a safe and practical option for appropriate patients, and will offer greater improvements in fitness, exercise adherence, cardiovascular risk factors, and intra-abdominal fat.
The prevalence of liver cirrhosis worldwide is rising due. The majority of the morbidity and mortality, which arises with cirrhosis, occurs due to the development of portal hypertension. In cirrhosis unexplained vasodilatation of the splanchnic circulation occurs contributing significantly to portal hypertension. I expect to confirm through my experiments that the ACE2/Ang 1-7/Mas axis (alternate RAS) is responsible for this vasodilatation and that antagonists targeting this system may have a ro ....The prevalence of liver cirrhosis worldwide is rising due. The majority of the morbidity and mortality, which arises with cirrhosis, occurs due to the development of portal hypertension. In cirrhosis unexplained vasodilatation of the splanchnic circulation occurs contributing significantly to portal hypertension. I expect to confirm through my experiments that the ACE2/Ang 1-7/Mas axis (alternate RAS) is responsible for this vasodilatation and that antagonists targeting this system may have a role in therapy.Read moreRead less
Calcification of the arteries is a ubiquitous finding in patients with end stage renal failure. It is often mirrored by disturbed bone metabolism. Increasing evidence suggests a close relationship between bone and vascular health. This study aims to determine the role of calciprotein particles as a mediator of calcification in bones and arteries. Translating these findings to renal patients will ultimately contribute to providing a scientific basis for developing treatment for these patients.