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Defining Phenotypic Variation In The Gut-to-brain Signalling Responses To Hexose Sugars.
Funder
National Health and Medical Research Council
Funding Amount
$321,564.00
Summary
There is a strong link between the incidence of obesity and consumption of sweetened beverages. The proposed studies will characterise (i) the pathway(s) by which sugars signal from the gut to the brain to regulate food intake, (ii) the role of gut peptides in this signalling, and (iii) the variations between individuals in these responses. This information will provide important insights as to why some individuals are more likely to gain weight in response to exposure to diets high in sugar.
The Role Of Arousal In The Pathogenesis Of Obstructive Sleep Apnea And Implications For Novel Therapeutic Treatments
Funder
National Health and Medical Research Council
Funding Amount
$297,888.00
Summary
This research forms part of a series of studies aimed at characterizing the relative importance of the various physiological causes (phenotypes) of obstructive sleep apnea (OSA) and has the potential to lead to individually tailored novel therapies according to these traits. Specifically, this proposed research will investigate the role of arousal from sleep (brief awakening) in OSA and explore methods of manipulating the arousal threshold as a new treatment approach for certain OSA patients.