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Advanced Population-based Methods To Evaluate And Inform Immunisation Policy And Practice
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Despite the overall success of immunisation programs, preventable infections continue to occur, with Aboriginal children suffering the most. I will study the health and vaccination records for 1.95 million children (98,000 Aboriginal) in New South Wales and Western Australia to see who is most at risk of vaccine preventable infections and why. The findings will aid development of strategies to target high-risk children and to optimise the benefits obtained from Australia’s immunisation program.
Enabling Technologies For Design And Delivery Of Novel Vaccines Against Infectious Diseases And Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$925,346.00
Summary
This grant will support research necessary to develop the next generation of vaccines. These will combat diseases caused by bacteria and viruses and can also be used to fight cancer. The broad range of application is made possible through the incorporation of simple molecular features that activate the immune system. The intellectual property that has been developed is protected by a patent portfolio some patents of which are already licenced to the pharmaceutical industry.
Applying Active Hospital-based Case Ascertainment To Assess Vaccine Effectiveness And Safety
Funder
National Health and Medical Research Council
Funding Amount
$258,741.00
Summary
Australia makes a considerable investment in vaccination, and the public are entitled to expect that vaccines are both safe and effective. The growing complexity of the vaccine schedule requires the development of new and flexible systems to monitor vaccine performance. This project aims to do this using surveillance nurses embedded in children's hospitals to actively find cases of diseases which are potentially vaccine-preventable as well as those which might have occurred as a side effect of v ....Australia makes a considerable investment in vaccination, and the public are entitled to expect that vaccines are both safe and effective. The growing complexity of the vaccine schedule requires the development of new and flexible systems to monitor vaccine performance. This project aims to do this using surveillance nurses embedded in children's hospitals to actively find cases of diseases which are potentially vaccine-preventable as well as those which might have occurred as a side effect of vaccination.Read moreRead less
Development Of A Self-adjuvanting Mucosal Vaccine Candidate Against Group A Streptococcus Using Lipid Core Technology
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Novel developments in drug/vaccine delivery are clearly to have enormous economic and social impacts. My research aim is to rationally design and develop vaccines against relevant diseases. By understanding the mechanism of protection against diseases, development of novel vaccines for the treatment of many diseases can be achieved. This would contribute enormously to the betterment of public health.
Reducing Vaccine Preventable Diseases In Children: Using National Active Hospital-based Surveillance To Evaluate And Improve Immunisation Program Performance
Funder
National Health and Medical Research Council
Funding Amount
$1,049,916.00
Summary
This proposal aims to evaluate and improve upon immunisation policy and programs for the prevention of severe childhood influenza and pertussis. Using our successful Paediatric Active Enhanced Disease Surveillance (PAEDS) network in 6 major children's hospitals across Australia, we will identify gaps in the evidence base needed to better control influenza and pertussis and in particular to ensure programs are delivered in such a way so as to address health inequalities.
Assessing Vaccine Effectiveness Of Publicly Funded Vaccination Programs In Queensland
Funder
National Health and Medical Research Council
Funding Amount
$99,883.00
Summary
I will measure how well three vaccines on the national immunisation schedule prevent disease in Queensland. Pertussis (whooping cough), rotavirus, and varicella (chicken-pox) vaccines will be assessed using routinely collected health data, such as disease notifications and hospitalisations, and vaccination data. The findings of this research will contribute to evaluating the effectiveness of these publicly funded vaccination programs and will provide an evidence base for future decision-making.
Protecting Australia From Future Swine Flu Pandemics-Functional And Structural Studies Of The H1N1 Swine Influenza A Surface Glycoprotein Hemagglutinin
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
The severity of the present and future pandemic strains of the swine flu will depend on the ability to contain and combat infection via pre-emptive development of appropriate vaccines and drugs. To this end, my study of the surface glycoprotein hemagglutinin, will help predict and prevent future swine influenza pandemics by identifying potentially pandemic strains to be targeted for early vaccine development.
Population-based Data Linkage And Modelling Studies To Evaluate And Inform Australia’s Immunisation Program
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Despite the overall success of immunisation programs, outbreaks of preventable diseases continue and Indigenous children still suffer a higher burden of illness. We will study a cohort of infants in New South Wales and data about their illnesses and vaccinations to provide accurate measures program performance. The findings will aid development of strategies to target high risk children, and more realistic models about future outcomes, so that the benefits of immunisation are optimised.
Evolution Of Pertussis Epidemics And Effect Of Genotypes On Infection Outcomes And Immunisation
Funder
National Health and Medical Research Council
Funding Amount
$657,781.00
Summary
Pertussis, or whooping cough, is caused by Bordetella pertussis. Despite high vaccine coverage, the incidence of pertussis has increased substantially in recent years in Australia. One of the contributing factors is changes in the pertussis strains. This project will determine the genetic composition and virulence characteristics of epidemic strains in Australia and investigate the effect of these strains on disease severity and vulnerability of vaccinated individuals to infection.
Vaccination Timeliness In Aboriginal And Non-Aboriginal Infants: Risk Factors For Delayed Vaccination And Impact On Disease Burden—a Record Linkage Study
Funder
National Health and Medical Research Council
Funding Amount
$538,183.00
Summary
Vaccination has had a significant impact, but preventable infections continue to occur, perhaps due to delayed uptake of scheduled doses. For the first time, we will link vaccination and other health records to: provide accurate estimates of the impact of vaccination; identify reasons for delayed vaccination; and quantify the expected reduction in disease burden if vaccination timeliness was improved. The study will help determine who would benefit most from efforts to improve timeliness.