RNA viruses are one of the last frontiers for globally significant infections. There ability to rapidly hide from the host's immune response and cause additional infections has made the ability to make vaccines very difficult. By studying patients that naturally and rapidly clear multiple infections we have identified strategies to conquer these highly divergent viruses. We are currently dedicated to trying to understand how we can mold this knowledge into a protective vaccine.
Structural Biology Of Malaria Parasite Invasion And Antibodies-mediated Inhibition
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
Malaria results in significant mortality but an effective vaccine does not yet exist. The Rh5-CyRPA-Ripr complex is essential for malaria parasite to invade erythrocytes and is the leading vaccine candidate. We aim to visualise the atomic details of the Rh5-CyRPA-Ripr complex during parasite invasion of erythrocytes and how antibodies neutralise this key protein complex. This information will advance knowledge on malaria parasite invasion, which will help to design an effective malaria vaccine.
A Worm-free World: Defeating Parasitic Helminths Via Global Integrated Control
Funder
National Health and Medical Research Council
Funding Amount
$2,714,215.00
Summary
My research goal is to conquer parasitic worm infestations globally. These parasites cause substantial illness and affect the poorest people. Programs that drug-treat infected individuals are neither effective nor sustainable. My research has shown additional strategies, such as vaccination and health education, are needed. My goal is to develop and field test a combination of interventions in different settings leading to long-term control and elimination of these ancient human scourges.