First-in-Field Study Of Mechanisms Operating In Post-Ebola Eye Disease
Funder
National Health and Medical Research Council
Funding Amount
$748,985.00
Summary
Ebola virus disease is a life-threatening illness with no treatment. Survivors of the disease are at risk of uveitis - inflammation inside the eye - related to the ability of Ebola virus to persist in the eye. Our research will examine the cellular and molecular events that occur in an eye that harbours Ebola virus. This work will be an important step towards the development of treatments for uveitis caused by Ebola virus.
Regulation Of ICAM-1 Expression In Human Retinal Endothelial Cells
Funder
National Health and Medical Research Council
Funding Amount
$565,967.00
Summary
Posterior uveitis is an inflammation that occurs within the eye and may result in blindness. Present treatments are not directed specifically at the inflamed tissues, and they may be ineffective and cause toxicity. This research aims to identify molecules controlling the entry into the eye from the bloodstream of the white blood cells that cause the disease. The results should suggest new targets for safer drugs to treat patients with posterior uveitis.