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Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Low-energy electron transport in soft-condensed biological matter. To obtain optimal accuracy and selectivity of ionising radiation based technologies requires an understanding and quantification of the underpinning fundamental physical processes. This project will focus on developing accurate theoretical models of low-energy electron transport in biological matter which account for new physical mechanisms.
How do biomolecules control excited-state dynamics? This project will use a combined theoretical and experimental approach to find out why non-fluorescent dyes become fluorescent when they bind certain biomolecules. This project's science will help guide the development of smart, biomimetic energy technologies and increase our understanding of how light powers living things.
EGFR-directed radioimmunotherapy combined with chemotherapy and DNA repair inhibition: development towards clinical application for aggressive cancers. Pancreatic ductal adenocarcinoma (PDAC) and triple negative breast cancer (TNBC) are aggressive diseases which lack effective therapies in clinical use. A novel and curative therapy was developed against PDAC and TNBC which involves targeted radiotherapy combined with chemotherapy and DNA damage response inhibition. This project will develop a “p ....EGFR-directed radioimmunotherapy combined with chemotherapy and DNA repair inhibition: development towards clinical application for aggressive cancers. Pancreatic ductal adenocarcinoma (PDAC) and triple negative breast cancer (TNBC) are aggressive diseases which lack effective therapies in clinical use. A novel and curative therapy was developed against PDAC and TNBC which involves targeted radiotherapy combined with chemotherapy and DNA damage response inhibition. This project will develop a “preclinical data package” comprising a biological rationale and preclinical evidence of safety and efficacy that together would justify an early phase clinical trial. This package includes the choice of formulations, mechanism of action and safety studies. This development will have an immediate impact for PDAC and TNBC patients and a future impact on other EGFR-positive cancers.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100433
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Optimising light harvesting using quantum transport. Observations of wavelike energy transport in photosynthetic systems have exposed the role of quantum mechanics in natural light harvesting. This project is a study of how light harvesting functions for an incoherent source like sunlight. In sunlight, energy transport occurs at steady state, a dramatically simpler regime than when a coherent source like lasers are used. This project will exploit this simplification to develop new methods for tr ....Optimising light harvesting using quantum transport. Observations of wavelike energy transport in photosynthetic systems have exposed the role of quantum mechanics in natural light harvesting. This project is a study of how light harvesting functions for an incoherent source like sunlight. In sunlight, energy transport occurs at steady state, a dramatically simpler regime than when a coherent source like lasers are used. This project will exploit this simplification to develop new methods for treating light harvesting in sunlight and apply them to a variety of natural and artificial systems. It will clarify how bacteria and plants harvest sunlight and lead to design principles that will enable artificial light harvesting to take advantage of quantum effects.Read moreRead less
Caged lanthanides for use in photo-dynamic therapy and near infra-red imaging. The early detection and effective treatment of cancer are two critical factors which determine survivability. This project will provide improved drugs for photo-dynamic therapy and develop emissive probes for near infra-red imaging to allow better discrimination between healthy and diseased tissue and improve subsequent treatment.