Next-generation epigenetic analysis: direct reading of DNA methylation. This project aims to develop a new molecular tool to directly and dynamically read chemical modifications on genomic DNA (epigenetics) by utilizing advanced nanomaterials with the unique features of Raman spectroscopy. Epigenetics affects cellular processes and controls genetic programs by turning them “on” and “off" but there is currently no direct method to measure modifications on DNA. A new technology will be designed to ....Next-generation epigenetic analysis: direct reading of DNA methylation. This project aims to develop a new molecular tool to directly and dynamically read chemical modifications on genomic DNA (epigenetics) by utilizing advanced nanomaterials with the unique features of Raman spectroscopy. Epigenetics affects cellular processes and controls genetic programs by turning them “on” and “off" but there is currently no direct method to measure modifications on DNA. A new technology will be designed to avoid complicated procedures/chemistry for DNA epigenetic analysis providing a specific molecular fingerprint. The anticipated outcomes include a new technique and advanced knowledge in nanomaterials and DNA functions, thus strengthening the economic viability of Australian manufacturing and biotechnology sectors.Read moreRead less
DNA exhibits new self-assembled structures due to clustered DNA methylation. This project aims to develop a technology to investigate detailed epigenetic patterns in DNA by directly interrogating the physical properties of DNA polymers in their native state. Epigenetics controls whether genes and genetic programs are turned on or off in living systems. The project will build on a recent discovery that key physical properties of native DNA polymers are strongly influenced by epigenetic patterns c ....DNA exhibits new self-assembled structures due to clustered DNA methylation. This project aims to develop a technology to investigate detailed epigenetic patterns in DNA by directly interrogating the physical properties of DNA polymers in their native state. Epigenetics controls whether genes and genetic programs are turned on or off in living systems. The project will build on a recent discovery that key physical properties of native DNA polymers are strongly influenced by epigenetic patterns created by living organisms. By fully understanding this phenomenon, this project aims to provide new tools for the study of epigenetics with broad potential applications in the life sciences, biotechnology and nanotechnology.Read moreRead less
Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanc ....Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanced ecological safety.Read moreRead less
Characterisation and Modelling of Nanostructured Soft Magnetic Materials for Advanced Electromagnetic Applications. This project bridges the gap between nanomagnetic materials and practical applications. The knowledge generated and the international collaborations with world class scientists established through this cutting-edge research project will strengthen the leading status of Australia in the field of nanoscience and nanotechnology. The research outcomes will stimulate the growth of world ....Characterisation and Modelling of Nanostructured Soft Magnetic Materials for Advanced Electromagnetic Applications. This project bridges the gap between nanomagnetic materials and practical applications. The knowledge generated and the international collaborations with world class scientists established through this cutting-edge research project will strengthen the leading status of Australia in the field of nanoscience and nanotechnology. The research outcomes will stimulate the growth of world class Australian industries and hence the national economy through the commercial manufacturing of hi-tech nanomagnetic materials and innovative smart devices and systems. High quality PhD and honours project students will be trained.Read moreRead less
Self-organised complex ionised gas systems for ordered nanometre-scale assemblies. This proposal is to develop the physical principles of nano-scale assembly processes in complex plasmas. Novel approaches for tailoring the plasma-grown building blocks and controllable deposition of ordered nanoparticle arrays on nanopatterned solids are targeted. The fundamentals of the multi-scale dynamic processes will be elucidated and existing techniques for developing new materials and electronic/photonic d ....Self-organised complex ionised gas systems for ordered nanometre-scale assemblies. This proposal is to develop the physical principles of nano-scale assembly processes in complex plasmas. Novel approaches for tailoring the plasma-grown building blocks and controllable deposition of ordered nanoparticle arrays on nanopatterned solids are targeted. The fundamentals of the multi-scale dynamic processes will be elucidated and existing techniques for developing new materials and electronic/photonic devices will be advanced. The expected outcomes are highly relevant for the nano-materials and optoelectronic technologies, rapidly emerging areas of high-tech industries worldwide.Read moreRead less
CNTs-modified polymer composites for tribological applications. The growth of the Australian economy relies on continuous improvements in all sectors of production, manufacturing, operation and management where tribology is playing a significant role. System failure relevant to wear and friction over years and its impact on the Australian economy have continued to be a challenge for the community in the new century. The project is at the forefront of materials research, and the outcomes will pro ....CNTs-modified polymer composites for tribological applications. The growth of the Australian economy relies on continuous improvements in all sectors of production, manufacturing, operation and management where tribology is playing a significant role. System failure relevant to wear and friction over years and its impact on the Australian economy have continued to be a challenge for the community in the new century. The project is at the forefront of materials research, and the outcomes will provide (1) novel technical ways to optimise tribological performance of industrial contacting components, and (2) development of new wear resistant materials. The project will give Australia a competitive edge in the advances of tribology and nanotechnologyRead moreRead less
The Nanotechnology Desalination Research Project - Low Energy Desalination Membranes. Population growth and global warming is rapidly increasing the strain placed on fresh water supplies. Environmentally sustainable solutions to this water shortage need to be found urgently. This project will develop new, low energy desalination technologies which can be powered by renewable energy sources, to enable desalination to be widely applied with low environmental impacts. It addresses several national ....The Nanotechnology Desalination Research Project - Low Energy Desalination Membranes. Population growth and global warming is rapidly increasing the strain placed on fresh water supplies. Environmentally sustainable solutions to this water shortage need to be found urgently. This project will develop new, low energy desalination technologies which can be powered by renewable energy sources, to enable desalination to be widely applied with low environmental impacts. It addresses several national priorities: Water - a critical resource; Transforming existing industries; Overcoming soil loss, salinity and acidity; Responding to climate change and variability; Frontier technologies and Advanced materials.Read moreRead less
Complex plasmas: self-organized dusty matter from nanotechnology to astrophysics. The importance of complex plasmas is based on their intricate self-organized behaviour, on their rich variety in nature and extensive use in the laboratory and advanced technologies. This project aims at breakthrough results advancing the fundamental knowledge and contributing to frontier technologies such as nanoelectronics and nanotechnology as well as reliability of space technological systems and communication ....Complex plasmas: self-organized dusty matter from nanotechnology to astrophysics. The importance of complex plasmas is based on their intricate self-organized behaviour, on their rich variety in nature and extensive use in the laboratory and advanced technologies. This project aims at breakthrough results advancing the fundamental knowledge and contributing to frontier technologies such as nanoelectronics and nanotechnology as well as reliability of space technological systems and communications. The project will boost fundamental and applied aspects of the Australian science as well as international collaborative links of Australian research and technology by allowing access and involvement to advanced multi-national programs and high-profile experiments such as those on board the International Space Station.Read moreRead less
TAILORING OF LAYERED DOUBLE HYDROXIDE NANOPARTICLES FOR EFFECTIVE DELIVERY OF BIOLOGICALLY ACTIVE PEPTIDES AND cDNAs. This project will lead to a new class of nanoparticle for effective peptide and DNA transfer, promising efficient drug delivery system with controllable loading and releasing and thus help maintain good health, particularly targeting neurological diseases. This project has also involved fundamental research into the nanomaterial science, surface chemistry, cell biochemistry and n ....TAILORING OF LAYERED DOUBLE HYDROXIDE NANOPARTICLES FOR EFFECTIVE DELIVERY OF BIOLOGICALLY ACTIVE PEPTIDES AND cDNAs. This project will lead to a new class of nanoparticle for effective peptide and DNA transfer, promising efficient drug delivery system with controllable loading and releasing and thus help maintain good health, particularly targeting neurological diseases. This project has also involved fundamental research into the nanomaterial science, surface chemistry, cell biochemistry and neuron sciences. Successful completion of the project will contribute to the development of advanced materials helping Australia advance and build the industrial competitiveness. Through this project highly skilled researchers will be well trained. Read moreRead less