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Pancreatic Islet Inflammation And Its Role In Diabetes And Islet Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Diabetes is a major health epidemic & diabetic complications are a major cause of morbidity and mortality in our community. My studies have increased our understanding of how inflammation contributes to diabetes but also directly led to the discovery of novel therapies that are been trialed in patients with type 1 diabetes undergoing islet cell transplants. My studies have increased our knowledge of the factors that lead to type 1 diabetes and the development of new treatments.
Gastric Counter-regulation Of Hypoglycaemia: Studies In Health And Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$357,193.00
Summary
Insulin injections are often needed to treat diabetes, but they can cause low blood sugar levels (hypoglycaemia), which are usually distressing, and sometimes fatal. The stomach is important in regulating blood sugar; in response to hypoglycaemia, it empties food much more rapidly, allowing carbohydrate to be absorbed faster to normalise blood sugar levels. The proposed studies will explore this important area, in order to develop better ways of preventing and treating hypoglycaemia.
Childhood Diabetes: Translating Evidence Into Practice
Funder
National Health and Medical Research Council
Funding Amount
$444,014.00
Summary
Type 1 diabetes is one of the most common chronic diseases of childhood. The burden of disease on the individual, their family and the community is enormous. The goal of this fellowship is to utilise evidence-based research to inform health policy and enhance the care of young people with diabetes. The proposal addresses patterns of disease in Australia, environmental triggers for diabetes, and care of the young person with diabetes through implementation of national evidence based clinical care ....Type 1 diabetes is one of the most common chronic diseases of childhood. The burden of disease on the individual, their family and the community is enormous. The goal of this fellowship is to utilise evidence-based research to inform health policy and enhance the care of young people with diabetes. The proposal addresses patterns of disease in Australia, environmental triggers for diabetes, and care of the young person with diabetes through implementation of national evidence based clinical care guidelines for type 1 diabetes.Read moreRead less
Intervening In The Natural History Of Type 1 Diabetes: An Integrated Approach
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
This Program brings together four of Australia’s top type 1 diabetes clinical and lab-based research teams. The program has three intersecting themes. The first theme, pathogenesis, focuses on early life and understanding why type 1 diabetes develops. The second theme, prevention, seeks to identifying new drugs to stop the disease from occurring. The third theme, treatment, aims to improve therapies to replace the cells that are destroyed during the disease process.
Transforming Mealtime Insulin Dosing Using An Innovative New Bolusing Calculator To Optimise Glycaemic Control In Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
People with type 1 diabetes require life-long insulin injections to maintain their blood glucose levels in the optimal range. Mealtime dose estimations based solely on carbohydrate have limited efficacy as they fail to take fat and protein into account. The aim of this project is to develop an evidence-based insulin bolusing calculator integrated into a smartphone app to enhance blood glucose control and reduce the daily burden of disease and the risk of life-threatening complications.
Free-Living Closed-Loop Insulin Delivery For Patients With Type 1 Diabetes: A Long-term Multi-centre Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,041,986.00
Summary
Closed loop technology for automating the delivery of insulin to patients with Type 1 diabetes has the potential to improve the lives of many with the disease. Though early prototypes are currently under evaluation in small studies, no studies have yet to date applied the technology in a large scale randomised trial. We propose to undertake such a study in order to demonstrate the utility of this technology and facilitate its eventual routine and widespread use in the community in the future.
Preservation And Generation Of Beta Cells In Type 1 Diabetes With Novel Mimetic Peptides
Funder
National Health and Medical Research Council
Funding Amount
$1,096,055.00
Summary
Type 1 diabetes (T1D) is an autoimmune disease that destroys insulin producing beta cells in the pancreas. It can cause heart and kidney disease, and nerve damage. T1D is treated with insulin injections that can cause life-threatening low blood sugar levels. We have developed a new treatment that may stop beta cell loss, generate new beta cells and remove the need for insulin injections in T1D patients. A positive outcome will identify a completely new T1D treatment option.
Type 1 Diabetes And The Metabolic Syndrome: Defining This Modern-day Phenotype, And Exploring The Effects Of Exercise On Glycaemic Control And Both Traditional And Novel Diabetes Complications
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
This research aims to define trends in the prevalence of, and complications associated with, metabolic syndrome in adults with type 1 diabetes, using the Australian National Diabetes Information Audit and Benchmarking Initiative (ANDIAB). Subsequently, a randomised controlled trial will examine the effect of exercise on glycaemic control and diabetes complications risk profiles in this group. These studies will thus address disease profiles and a potential beneficial clinical intervention.
Investigating Pathways To Alleviate The Burden Of Diabetes And Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
Diabetes affects more than 1.2 million Australians and up to 40% of these will develop complications including kidney disease. Excess blood sugar as the result of diabetes can accelerate a biochemical process called advanced glycation, which permanently alters proteins affecting their structure and function. My research will focus on identifying new therapies to target advanced glycation as well as dysfunction of cell power stations, mitochondria which is caused by advanced glycation.
Childhood Diabetes: Prediction, Prevention And Preservation Of Beta Cells
Funder
National Health and Medical Research Council
Funding Amount
$577,189.00
Summary
Childhood onset type 1 diabetes is a severe life-long disease that has a major impact on the child and their family. While studies have attempted to modify the immune system before or after diagnosis, few clinical trials have recruited young children. The overarching goal of this fellowship is to improve the lives of young people with diabetes, through a multifaceted program of ground-breaking research aimed at prediction, prevention and preservation of insulin producing ?-cells in the pancreas.