Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Aus ....Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Australia, and consolidate their roles as leading outlets for Indigenous content and coverage. These outcomes are also expected to improve public understanding of issues affecting Indigenous Australians and contribute to more informed and inclusive policy discussions.Read moreRead less
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100148
Funder
Australian Research Council
Funding Amount
$460,000.00
Summary
TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Au ....TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Australian media ecology, and systematic analyses of how public communication takes place via social media provide rich insights into a range of issues and debates of high importance to our society.Read moreRead less
When Your Face is Your ID: Public Responses to Automated Facial Recognition. This project would explore public attitudes toward the use of facial recognition technology in public and commercial spaces, schools, and workplaces with a national survey, focus group interviews, and four case studies. The project aims to generate new knowledge about public attitudes through a multi-method interdisciplinary approach that anticipates the future of the technology by studying its use in China. Expected ou ....When Your Face is Your ID: Public Responses to Automated Facial Recognition. This project would explore public attitudes toward the use of facial recognition technology in public and commercial spaces, schools, and workplaces with a national survey, focus group interviews, and four case studies. The project aims to generate new knowledge about public attitudes through a multi-method interdisciplinary approach that anticipates the future of the technology by studying its use in China. Expected outcomes include public reports on the survey and case studies, seven academic journal articles, and a book. The research would provide significant benefits by contributing new knowledge about how to implement the technology in accordance with Australian commitments to civil rights, ethics and democratic values.
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Breaking silences: media and the Child Abuse Royal Commission. This project aims to analyse the role of media, journalism and social media activism in the Royal Commission into Institutional Responses to Child Sexual Abuse (2013-17) (RCIRCSA). By focusing on the nexus between media and commissions of inquiry in the digital era, the project will investigate the impacts of a rapidly changing media environment on this national 'listening' exercise. The project will use a case study approach to crit ....Breaking silences: media and the Child Abuse Royal Commission. This project aims to analyse the role of media, journalism and social media activism in the Royal Commission into Institutional Responses to Child Sexual Abuse (2013-17) (RCIRCSA). By focusing on the nexus between media and commissions of inquiry in the digital era, the project will investigate the impacts of a rapidly changing media environment on this national 'listening' exercise. The project will use a case study approach to critically analyse the role of a transitioning local, national and social media in triggering, reporting on and keeping alive the findings of the royal commission, ensuring victims of institutional child sexual abuse are heard, and justice is upheld.Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
So what do you do? Graduates in the Creative and Cultural Industries. This project plans to analyse national graduate employment in Australia’s creative and cultural industries, and compare the utility of 'creative' and 'cultural' models for tracking employment outcomes. Although the image of work in the creative and cultural industries is attractive to students and course planners alike, international evidence suggests graduates face very poor employment prospects. The project plans to use a pr ....So what do you do? Graduates in the Creative and Cultural Industries. This project plans to analyse national graduate employment in Australia’s creative and cultural industries, and compare the utility of 'creative' and 'cultural' models for tracking employment outcomes. Although the image of work in the creative and cultural industries is attractive to students and course planners alike, international evidence suggests graduates face very poor employment prospects. The project plans to use a proven model for mapping creative graduates to compare the value of creative degrees for the creative workforce in two nations, Australia and the United Kingdom; and to use sophisticated quantitative analysis of national datasets and interviews to produce a comprehensive study of creative graduate work.Read moreRead less
Fringe to Famous: Contemporary Australian Culture as an Innovation System. The project examines the crossover between ‘alternative’ and ‘mainstream’ cultural production in Australia, identifying ways in which a hybridisation between the avant garde and the popular promotes the development of cultural industries. It will conduct a detailed study of five cases: comedy (Working Dog and the Chaser), music (Mental as Anything, Paul Kelly and Nick Cave), visual arts/graphic design (Mambo Graphics), sh ....Fringe to Famous: Contemporary Australian Culture as an Innovation System. The project examines the crossover between ‘alternative’ and ‘mainstream’ cultural production in Australia, identifying ways in which a hybridisation between the avant garde and the popular promotes the development of cultural industries. It will conduct a detailed study of five cases: comedy (Working Dog and the Chaser), music (Mental as Anything, Paul Kelly and Nick Cave), visual arts/graphic design (Mambo Graphics), short film (Tropfest) and games development (Freeplay). It will identify the conditions which have allowed crossover between the avant-garde and the mainstream and produce recommendations for policy both in cultural development and the development of creative industries.Read moreRead less