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Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100148
Funder
Australian Research Council
Funding Amount
$460,000.00
Summary
TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Au ....TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Australian media ecology, and systematic analyses of how public communication takes place via social media provide rich insights into a range of issues and debates of high importance to our society.Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
So what do you do? Graduates in the Creative and Cultural Industries. This project plans to analyse national graduate employment in Australia’s creative and cultural industries, and compare the utility of 'creative' and 'cultural' models for tracking employment outcomes. Although the image of work in the creative and cultural industries is attractive to students and course planners alike, international evidence suggests graduates face very poor employment prospects. The project plans to use a pr ....So what do you do? Graduates in the Creative and Cultural Industries. This project plans to analyse national graduate employment in Australia’s creative and cultural industries, and compare the utility of 'creative' and 'cultural' models for tracking employment outcomes. Although the image of work in the creative and cultural industries is attractive to students and course planners alike, international evidence suggests graduates face very poor employment prospects. The project plans to use a proven model for mapping creative graduates to compare the value of creative degrees for the creative workforce in two nations, Australia and the United Kingdom; and to use sophisticated quantitative analysis of national datasets and interviews to produce a comprehensive study of creative graduate work.Read moreRead less
Fringe to Famous: Contemporary Australian Culture as an Innovation System. The project examines the crossover between ‘alternative’ and ‘mainstream’ cultural production in Australia, identifying ways in which a hybridisation between the avant garde and the popular promotes the development of cultural industries. It will conduct a detailed study of five cases: comedy (Working Dog and the Chaser), music (Mental as Anything, Paul Kelly and Nick Cave), visual arts/graphic design (Mambo Graphics), sh ....Fringe to Famous: Contemporary Australian Culture as an Innovation System. The project examines the crossover between ‘alternative’ and ‘mainstream’ cultural production in Australia, identifying ways in which a hybridisation between the avant garde and the popular promotes the development of cultural industries. It will conduct a detailed study of five cases: comedy (Working Dog and the Chaser), music (Mental as Anything, Paul Kelly and Nick Cave), visual arts/graphic design (Mambo Graphics), short film (Tropfest) and games development (Freeplay). It will identify the conditions which have allowed crossover between the avant-garde and the mainstream and produce recommendations for policy both in cultural development and the development of creative industries.Read moreRead less
Increasing Visitor Frequency: approach to understanding and forecasting how cultural attraction visitors respond to various incentives to increase visitation rates. Museums have been steadily losing visitors over the past decade. While current research indicates that this may be attributed to greater leisure competition, little is understood about how people make choices to visit or not to visit cultural attractions. The aim of this project is to develop, demonstrate and test a Random Utility Th ....Increasing Visitor Frequency: approach to understanding and forecasting how cultural attraction visitors respond to various incentives to increase visitation rates. Museums have been steadily losing visitors over the past decade. While current research indicates that this may be attributed to greater leisure competition, little is understood about how people make choices to visit or not to visit cultural attractions. The aim of this project is to develop, demonstrate and test a Random Utility Theory (RUT)-based modelling approach allowing managers of cultural attractions to understand and predict the likely visitation consequences of potential initiatives. We wish to model visitor choices of museums versus other competing attractions to allow museums to identify specific strategic actions (or combinations) to achieve organisational goals.Read moreRead less
Memories of utopia: Destroying the past to create the future (300-650 CE). This project aims to examine the evidence for competing utopian ideologies in early Christianity, which was a prelude to the later clash with Islam from the seventh century onward. Evidence from pagan-Jewish-Christian conflicts in Late Antiquity (300-650 CE) shows that violent destruction of the past is not exclusive to fringe religious groups. These past conflicts are relevant for understanding the conflict in the Middle ....Memories of utopia: Destroying the past to create the future (300-650 CE). This project aims to examine the evidence for competing utopian ideologies in early Christianity, which was a prelude to the later clash with Islam from the seventh century onward. Evidence from pagan-Jewish-Christian conflicts in Late Antiquity (300-650 CE) shows that violent destruction of the past is not exclusive to fringe religious groups. These past conflicts are relevant for understanding the conflict in the Middle East, precisely because analysis of the sources shows that, in intra- and inter-religious conflicts in Late Antiquity in this same geographic region, violent destruction of the past was a propensity in mainstream religion.Read moreRead less
Locating the mobile: intergenerational locative media practices in Tokyo, Melbourne and Shanghai. From providing convenience at a fingertip to helping criminal investigations, using locative media has become an essential part of everyday life for individuals, families, businesses and government. Responding to this nascent phenomenon, this project will provide the first cross-cultural, intergenerational study of locative media use.