The Australian Centre of Excellence in Twin Research will build on the Australian Twin Registry, which for 30 years has played an integral part in health & medical research. The new Centre aims to expand a state-of-the-art resource for conducting research, bring together leading national and international researchers from across disciplines, and build capacity in people, techniques, and expertise to continue to enable twin research to address major health and medical issues.
Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Mothers’ And Their Children’s Health Study: Understanding Disparities In Health And Health Service Utilisation Among Australian Families
Funder
National Health and Medical Research Council
Funding Amount
$684,744.00
Summary
The Mothers’ and their Children’s Health study will advance understanding of the risks to child health and development and help guide health policies for families across Australia. It builds on 17 years of data from a leading study of Australian women’s health with a new survey on all the children of 4000 mothers from that study. It is uniquely placed to investigate how the history of maternal and family characteristics affects the health and development of all the children in a family.
The meaning of home for children following parental separation. This project aims to identify the meaning of home for children in separated families by interviewing children and parents about children’s experiences of home and homemaking. Since most children now traverse two households, there needs to be an increasing emphasis in policy, law and professional practice on listening to children regarding their post-separation living arrangements. By describing and analysing home for children, the p ....The meaning of home for children following parental separation. This project aims to identify the meaning of home for children in separated families by interviewing children and parents about children’s experiences of home and homemaking. Since most children now traverse two households, there needs to be an increasing emphasis in policy, law and professional practice on listening to children regarding their post-separation living arrangements. By describing and analysing home for children, the project will provide a solid basis for shifting the prevailing focus on parents’ needs in application of the law toward more child-responsive parenting arrangements. This new knowledge will support parents and professionals to achieve child-responsive approaches to post-separation parenting arrangements, reducing potentially adverse impacts of parental separation on children, and benefitting children, families and the community.Read moreRead less
Ready to launch? young Australians’ work and family transitions. This project aims to establish reasons for young Australians delaying life-course milestones such as nest leaving and marriage. Are we seeing a shift of these milestones from “cornerstones” that lay the foundations for accomplishment to “capstones” that depend on economics accomplishments in areas such as employment? The project will investigate the timing of and conditions surrounding young Australians’ economic accomplishments an ....Ready to launch? young Australians’ work and family transitions. This project aims to establish reasons for young Australians delaying life-course milestones such as nest leaving and marriage. Are we seeing a shift of these milestones from “cornerstones” that lay the foundations for accomplishment to “capstones” that depend on economics accomplishments in areas such as employment? The project will investigate the timing of and conditions surrounding young Australians’ economic accomplishments and key household transitions. This will provide significant benefits such as identifying the economic, personal and family drivers of life-course transitions that are consequential for Australians' health, economic and social well-being, and use of public assistance programs.Read moreRead less
The 'long arm of the job': Improving parents' jobs and child development. This project aims to identify the priority job stressors that impact working families' wellbeing and child development, and to generate innovative job-based strategies to reduce work-family conflicts for working parents. Conflicts between work and family are common in Australia, reported by one in three parents. These affect productivity, family relationships and ultimately, child development. Evidence reveals that employe ....The 'long arm of the job': Improving parents' jobs and child development. This project aims to identify the priority job stressors that impact working families' wellbeing and child development, and to generate innovative job-based strategies to reduce work-family conflicts for working parents. Conflicts between work and family are common in Australia, reported by one in three parents. These affect productivity, family relationships and ultimately, child development. Evidence reveals that employers have struggled to implement family-friendly practices despite recent national policy initiatives. Using national cohort data and industry partnerships, this project investigates solutions to this urgent national dilemma to benefit those most affected by parents' job stressors – working parents and their children.
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Enhancing mothers' engagement with the workforce in the preschool years. Increasing the workforce participation of mothers is a key national policy agenda. This project will produce unique data that provides insights into how leave arrangements, childcare, flexibility, job characteristics and individual circumstances interact to influence mothers' workforce engagement and how this varies for different groups of mothers.
Post-separation co-parenting apps: Can they help families avoid conflict? This project aims to examine the role and effectiveness of smartphone apps in supporting families to respond to the many challenges of post-separation co-parenting. In an increasingly digital landscape where poor app choices can have serious consequences for families, this knowledge is urgently needed by parents and family law practitioners. This project expects to deliver a comprehensive understanding of the benefits and ....Post-separation co-parenting apps: Can they help families avoid conflict? This project aims to examine the role and effectiveness of smartphone apps in supporting families to respond to the many challenges of post-separation co-parenting. In an increasingly digital landscape where poor app choices can have serious consequences for families, this knowledge is urgently needed by parents and family law practitioners. This project expects to deliver a comprehensive understanding of the benefits and risks of digital divorce apps. Expected outcomes include the first web-based decision-making tool to help separated parents make important decisions about managing post-separation communication. This should provide significant benefits, including a reduced risk of parental conflict and better outcomes for children.Read moreRead less
A Solution Based Approach Developing Child Health Research With A Focus On Preventive Interventions For Common Childhood
Funder
National Health and Medical Research Council
Funding Amount
$2,599,538.00
Summary
There is an increasing recognition that research into child health should focus not only on disease but also on common childhood disorders such as obesity, depression and poor literacy. In addition, such research should include solution-based activity. That is, child health research should have an active program of testing new interventions to prevent the onset of disorders, or to allow optimal early management. The Murdoch Childrens Research Institute, the largest Australian child health resear ....There is an increasing recognition that research into child health should focus not only on disease but also on common childhood disorders such as obesity, depression and poor literacy. In addition, such research should include solution-based activity. That is, child health research should have an active program of testing new interventions to prevent the onset of disorders, or to allow optimal early management. The Murdoch Childrens Research Institute, the largest Australian child health research institute, is in a very good position to develop Australia's capacity further with regard to a coordinated research program into preventative interventions in child health. This is because of: - the Institute's location at the Royal Children's Hospital, Melbourne, the largest paediatric health service provider in Australia - the many individual relevant research projects that are already occurring in MCRI - the strong existing teams of researchers with skills in many different fields of child health such as psychology, speech pathology, clinical-medical care, epidemiology and biostatistics, and laboratory science including genetics. This capacity building program will coordinate population health work to develop the knowledge and skills of eight population health researchers. This development will occur within the context of an internationally competitive research program with structured continuing education and training to promote public health leadership. The capacity building program will develop skills not only in study design, conduct and analysis, but also in collaboration and the translation of research findings into better health services, government policy and parental knowledge to prevent problems and improve the health and well being of children and their families. To care for children in the best way, parents, families, schools, health care providers, and government need the best evidence base possible on the prevention of common child disorders.Read moreRead less
The Consequences of the Mental Load for Australian Families. This project aims to investigate the mental load; a structure of household work that combines cognitive and emotional labour. While there are theoretical understandings of the mental load, there is a dearth of quantitative research. This project expects to develop a consistent and reliable measure of the mental load and an understanding of its impacts on Australian families. The expected outcomes of the project include a comprehensive ....The Consequences of the Mental Load for Australian Families. This project aims to investigate the mental load; a structure of household work that combines cognitive and emotional labour. While there are theoretical understandings of the mental load, there is a dearth of quantitative research. This project expects to develop a consistent and reliable measure of the mental load and an understanding of its impacts on Australian families. The expected outcomes of the project include a comprehensive measurement of the mental load both in Australia and abroad. This will allow for the development of policy alleviating its impacts on caregivers, particularly mothers, and assist workplaces and Government in incorporating women into employment to reduce gender inequality.Read moreRead less