Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
The meaning of home for children following parental separation. This project aims to identify the meaning of home for children in separated families by interviewing children and parents about children’s experiences of home and homemaking. Since most children now traverse two households, there needs to be an increasing emphasis in policy, law and professional practice on listening to children regarding their post-separation living arrangements. By describing and analysing home for children, the p ....The meaning of home for children following parental separation. This project aims to identify the meaning of home for children in separated families by interviewing children and parents about children’s experiences of home and homemaking. Since most children now traverse two households, there needs to be an increasing emphasis in policy, law and professional practice on listening to children regarding their post-separation living arrangements. By describing and analysing home for children, the project will provide a solid basis for shifting the prevailing focus on parents’ needs in application of the law toward more child-responsive parenting arrangements. This new knowledge will support parents and professionals to achieve child-responsive approaches to post-separation parenting arrangements, reducing potentially adverse impacts of parental separation on children, and benefitting children, families and the community.Read moreRead less
Enhancing mothers' engagement with the workforce in the preschool years. Increasing the workforce participation of mothers is a key national policy agenda. This project will produce unique data that provides insights into how leave arrangements, childcare, flexibility, job characteristics and individual circumstances interact to influence mothers' workforce engagement and how this varies for different groups of mothers.
Post-separation co-parenting apps: Can they help families avoid conflict? This project aims to examine the role and effectiveness of smartphone apps in supporting families to respond to the many challenges of post-separation co-parenting. In an increasingly digital landscape where poor app choices can have serious consequences for families, this knowledge is urgently needed by parents and family law practitioners. This project expects to deliver a comprehensive understanding of the benefits and ....Post-separation co-parenting apps: Can they help families avoid conflict? This project aims to examine the role and effectiveness of smartphone apps in supporting families to respond to the many challenges of post-separation co-parenting. In an increasingly digital landscape where poor app choices can have serious consequences for families, this knowledge is urgently needed by parents and family law practitioners. This project expects to deliver a comprehensive understanding of the benefits and risks of digital divorce apps. Expected outcomes include the first web-based decision-making tool to help separated parents make important decisions about managing post-separation communication. This should provide significant benefits, including a reduced risk of parental conflict and better outcomes for children.Read moreRead less
Transition to adulthood in greater Jakarta: A longitudinal perspective. Interviewing 3,000 young adult Indonesians at two points in time, this project examines whether their economic and social outcomes change across time or whether early experience determines longer-term outcomes. What are the factors involved in transition to adulthood among young people in a rapidly developing metropolis of a developing country?
Mental Health Of Young People With Developmental Disabilities
Funder
National Health and Medical Research Council
Funding Amount
$5,622,916.00
Summary
Mental health problems of people with developmental disabilities are a substantial public health problem. A large Australian study shows that the problem begins early and persists without intervention. We will evaluate the Stepping Stones Triple P model of parenting early intervention after adding newly developed modules for specific causes of ID. The effectiveness of the program across three states will be evaluated.
Understanding an important aspect of current-day family dynamics: the institution of repartnering in Australia. Families are at the core of Australia's social fabric. Understanding their dynamics assists in developing good policies and mechanisms to support them. Repartnering is an important aspect of current-day family dynamics. Yet we know relatively little about how these partnerships operate. This project will illuminate the patterns and issues central to repartnering and provide a significa ....Understanding an important aspect of current-day family dynamics: the institution of repartnering in Australia. Families are at the core of Australia's social fabric. Understanding their dynamics assists in developing good policies and mechanisms to support them. Repartnering is an important aspect of current-day family dynamics. Yet we know relatively little about how these partnerships operate. This project will illuminate the patterns and issues central to repartnering and provide a significant contribution to social research. Results from this study will equip policy makers with appropriate knowledge to develop policies aimed at assisting families. The findings will contribute to growing international knowledge on family dynamics in repartnered relationships, as well as strengthen Australia's social and economic fabric through stronger families.Read moreRead less
Do Australian parents want both a son and a daughter? From the late 1990s, policy makers became more aware of the importance of fertility in influencing population age structure and growth rates in Australia. The proposed project will augment our understanding of fertility dynamics both current, and over high and low fertility regimes. It will also highlight an important factor in fertility decision-making. There is considerable speculation on the impact of shifting gender-role attitudes on sex ....Do Australian parents want both a son and a daughter? From the late 1990s, policy makers became more aware of the importance of fertility in influencing population age structure and growth rates in Australia. The proposed project will augment our understanding of fertility dynamics both current, and over high and low fertility regimes. It will also highlight an important factor in fertility decision-making. There is considerable speculation on the impact of shifting gender-role attitudes on sex preference, but evidence supporting this is mixed. By developing a deeper understanding of the factors influencing progression to having more children we will be better able to predict fertility trends and provide support to Australian parents. Read moreRead less
Understanding The Connections Between Aboriginal And Torres Strait Islander Culture, Health And Wellbeing To Support Action To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$1,915,802.00
Summary
Little is known about the inter-relationship of cultural factors and Aboriginal and Torres Strait Islander health outcomes and these relationships have not been quantified. Through a large cohort study, this research will produce data that combines standard health measures with newly developed quantitative measures of cultural factors, supported by data linkage infrastructure. Robust analytical methods will be used to inform policy and program development.
Predicting Renal, Ophthalmic, And Heart Events In The Aboriginal Community – THE PROPHECY Study
Funder
National Health and Medical Research Council
Funding Amount
$2,574,486.00
Summary
Up to 30% of adult Aboriginal people have diabetes yet our knowledge of the causes and predictors of complications remain incomplete. We have established the PROPHECY Study to assess the levels of complications in Aboriginal people with diabetes; to understand the way that these complications occur, and identify what clinical, social and genetic factors could predict who will get those complications to guide clinical management and prevention.