Adoptive Cell Transfer Incorporating Vaccination (ACTIV) Therapy For Cancer
Funder
National Health and Medical Research Council
Funding Amount
$601,950.00
Summary
We have made a breakthrough in a new treatment for cancer that can destroy large tumours in mice. The treatment involves a transfusion of white blood cells and an injection of a vaccine. In this project, we will seek to understand how the treatment works, and apply it to human white blood cells in preparation for a clinical trial in cancer patients.
Development Of Cancer Immunotherapy Using Gene-engineered T Cells In A Self-antigen Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$428,602.00
Summary
Killer T lymphocytes can penetrate tumours and their transfer into cancer patients has demonstrated some encouraging results, but this form of therapy and other approaches including vaccination remain ineffective in most cancer patients. In this project, we propose to improve the tumour trafficking and anti-tumour activities of killer cells by genetically engineering them with proteins that will enable them to recognise and destroy cancer cells.
Promoting physical activity and wellbeing of rural- and regional-living girls. This research will attempt to improve the physical activity levels and the physical and mental wellbeing of girls who live in disadvantaged and isolated rural and regional areas. This will be achieved by working with the girls to find ways to improve their involvement in sport and active recreation. This information will be used to develop, implement and evaluate a year-long sport and active recreation program that ....Promoting physical activity and wellbeing of rural- and regional-living girls. This research will attempt to improve the physical activity levels and the physical and mental wellbeing of girls who live in disadvantaged and isolated rural and regional areas. This will be achieved by working with the girls to find ways to improve their involvement in sport and active recreation. This information will be used to develop, implement and evaluate a year-long sport and active recreation program that is offered in both schools and the community. The research will occur in Victoria and will involve girls in years 7-9 of secondary school. It will involve the sports of tennis and football (soccer) as well as the active recreation opportunities offered by the YMCA.Read moreRead less
A randomised trial of an intervention to maintain alcohol management practices in community sporting clubs. Despite significant investment in implementation, many public health initiatives fail to persist when program funding and resources are reduced, limiting the benefits to the community. This project will investigate the effectiveness of a web-based intervention in sustaining the impact of an alcohol management intervention in community sports clubs.
E-health communication strategy and design: evaluating the influence of new media interventions on the health of patients from vulnerable populations. We must learn how to make better use of new communication technologies to assist in preventative health care, especially to help those who are most vulnerable to poor health in our society. This project will design, implement and evaluate the impact of new communication interventions that can be used to improve the overall health of Australians.
An Integrated Approach For The Efffective Adoptive Immunotherapy Of Cancer
Funder
National Health and Medical Research Council
Funding Amount
$468,119.00
Summary
Killer T lymphocytes can penetrate tumors and their transfer into cancer patients has demonstrated some encouraging results, but this form of immunotherapy remain ineffective in most cancer patients. We propose to improve the tumor trafficking and anti-tumor activities of killer cells by genetically engineering them with proteins that will enable them to recognise and destroy cancer cells. The outcomes of this project will validate this novel approach for treatment of cancer patients.
Reducing alcohol misuse: The efficacy of a comprehensive accreditation intervention in community sports clubs. The prevention of alcohol misuse is increasingly recognised as a priority by State and Commonwealth governments, and the community alike. A similar increasing recognition of the role of sport in the occurrence of such misuse has resulted in a call for action in this community setting. Very limited data are available regarding effective intervention strategies in sports clubs. The propos ....Reducing alcohol misuse: The efficacy of a comprehensive accreditation intervention in community sports clubs. The prevention of alcohol misuse is increasingly recognised as a priority by State and Commonwealth governments, and the community alike. A similar increasing recognition of the role of sport in the occurrence of such misuse has resulted in a call for action in this community setting. Very limited data are available regarding effective intervention strategies in sports clubs. The proposed intervention directly addresses this knowledge deficit. In addressing the culture of excessive alcohol consumption in sports clubs, the intervention, should it be effective, has the potential to contribute to a reduction in both short and long term alcohol harms in Australia.Read moreRead less
The role of taxes and subsidies in promoting healthy lifestyles: an economic analysis. This project will look at two critically important policy relevant questions in public health terms - obesity prevention and changing consumption patterns with respect to drinks consumption, including alcohol.
Mis-reporting, adaptation and anchoring: the implications for self assessed health. In terms of targeting scarce public health resources, information concerning the true health status of different social groups is important. This project will provide more accurate information on the health of the Australian population using data already collected on a routine basis. Resources can then be targeted to reduce health inequalities.
The efficacy of a referral and physical activity program for survivors of prostate cancer. Although survival rates of prostate cancer are approximately 83 per cent with earlier detection and improved treatment modalities, prostate cancer survivors are at an increased risk of dying from co-morbidities, which may be prevented or ameliorated through participation in physical activity. This project aims to establish an effective and sustainable referral and physical activity program to improve the ....The efficacy of a referral and physical activity program for survivors of prostate cancer. Although survival rates of prostate cancer are approximately 83 per cent with earlier detection and improved treatment modalities, prostate cancer survivors are at an increased risk of dying from co-morbidities, which may be prevented or ameliorated through participation in physical activity. This project aims to establish an effective and sustainable referral and physical activity program to improve the health outcomes of prostate cancer survivors by utilising the influence of clinicians in their delivery of information to patients. This concept of a referral and physical activity program has the potential to translate across all cancer tumour streams to reduce the physiological and psychological burden associated with living with cancer.Read moreRead less