I am a molecular geneticist with a special interest in molecular pathology determining the inherited and somatic genetic events that predispose to, and advance cancer development. Much of this work has immediate translatability to clinical genetics practi
I am cellular immunologist determining the important host immune cell types and effector molecules that control tumour initiation, growth, and metastasis.
Cancer immunology has emerged as a fundamental discipline of oncology and overwhelming new data from large patient studies reveals the importance of the immune reaction in patient prognosis. Professor Smyth has established a large body of work indicating that the immune reaction is rate limiting for the development of tumours. His previous fundamental work forms a platform to launch new studies that will greatly increase the sophistication with which we understand the various immune mechanisms t ....Cancer immunology has emerged as a fundamental discipline of oncology and overwhelming new data from large patient studies reveals the importance of the immune reaction in patient prognosis. Professor Smyth has established a large body of work indicating that the immune reaction is rate limiting for the development of tumours. His previous fundamental work forms a platform to launch new studies that will greatly increase the sophistication with which we understand the various immune mechanisms that control tumour initiation, growth and metastases. It is a major goal of Professor Smyth’s Australia Fellowship to understand why some tumours may be controlled by the immune response while others are apparently not. He has established mouse models of cancer where these questions can be directly addressed for the first time.Read moreRead less
My research straddles biochemistry, cell biology and immunology. I am interested in the mechanisms of antigen presentation by dendritic cells, and the functions of the cystatin family of protease inhibitors.
My research is to learn more of the genetic and epigenetic mechanisms governing the development of the reproductive cell lineage, or the cells that make eggs and sperm. My research is required to better understand human reproduction and human embryonic, fetal and neonatal development, and will help in the treatment of diseases affecting these processes.
I am a pharmacologist-cell biologist-molecular biologist and chemist examining the metabolism of iron in normal and neoplastic cells and the development of iron chelators for the treatment of a variety of diseases e.g., ?-thalassaemia and cancer.