Treating Equine Laminitis. This project aims to explore the causes of equine laminitis, and to work with a newly-established Australian biopharma company to develop the world's first anti-laminitis medication. Equine laminitis is a painful, crippling disease of the foot, often necessitating euthanasia, and is the second-most common cause of death in domestic horses. In 2007, a landmark study identified insulin toxicity as a primary cause of laminitis, and subsequent research has identified over- ....Treating Equine Laminitis. This project aims to explore the causes of equine laminitis, and to work with a newly-established Australian biopharma company to develop the world's first anti-laminitis medication. Equine laminitis is a painful, crippling disease of the foot, often necessitating euthanasia, and is the second-most common cause of death in domestic horses. In 2007, a landmark study identified insulin toxicity as a primary cause of laminitis, and subsequent research has identified over-stimulation of the IGF-1 receptor as the most likely mechanism. This project aims to prove that mechanism and to develop an effective treatment.Read moreRead less
Gastrointestinal hormones: linking insulin dysregulation and laminitis. This project aims to identify the earliest pathogenic factors of disease by investigating two key hormones, ghrelin and GLP-2, and whether a specific genetic mutation underlies insulin dysregulation. Using innovative approaches the project will enable the identification of at-risk animals and pinpoint novel treatment strategies. In the long term improved disease treatment and prevention will reduce the suffering associated w ....Gastrointestinal hormones: linking insulin dysregulation and laminitis. This project aims to identify the earliest pathogenic factors of disease by investigating two key hormones, ghrelin and GLP-2, and whether a specific genetic mutation underlies insulin dysregulation. Using innovative approaches the project will enable the identification of at-risk animals and pinpoint novel treatment strategies. In the long term improved disease treatment and prevention will reduce the suffering associated with painful and often lethal co-morbidities.Read moreRead less