Planning female and male vaccination and cervical screening strategies to achieve optimal prevention of HPV-related disease. The findings from this research will inform the development of public health policy on the most cost-effective utilisation of resources for preventing cervical, anogenital and head/neck cancers, and genital warts, in women and men, due to human papillomavirus (HPV). We will evaluate strategies for using emerging screening and vaccine technologies to prevent HPV-related dis ....Planning female and male vaccination and cervical screening strategies to achieve optimal prevention of HPV-related disease. The findings from this research will inform the development of public health policy on the most cost-effective utilisation of resources for preventing cervical, anogenital and head/neck cancers, and genital warts, in women and men, due to human papillomavirus (HPV). We will evaluate strategies for using emerging screening and vaccine technologies to prevent HPV-related disease, and assess potential adverse outcomes of vaccination. Men are currently not covered by routine vaccination or screening programs; this research will assess the benefit to men of vaccinating women only, and will consider the impact of vaccination and other interventions targeted towards men.Read moreRead less
Automated 3-Dimensional Biomedical Registration for Whole-body Images from Combined PET/CT Scanners. This project will aid rapid assimilation of very large medical imaging datasets from different imaging devices, and will have clinical applications in diagnosis and treatment and improve patient care. The research, when extended to protein registration, will facilitate analysis of DNA and advance research in bioinformatics and biotechnology. The research could also be used for target recognition, ....Automated 3-Dimensional Biomedical Registration for Whole-body Images from Combined PET/CT Scanners. This project will aid rapid assimilation of very large medical imaging datasets from different imaging devices, and will have clinical applications in diagnosis and treatment and improve patient care. The research, when extended to protein registration, will facilitate analysis of DNA and advance research in bioinformatics and biotechnology. The research could also be used for target recognition, mosaic construction, content-based retrieval, in remote sensing and multimedia. Benefits to Australia include the provision of a readily adaptable image registration program for patient care (e.g., early detection of cancers, dementia), cutting-edge research, high-quality training for students, and encouraging international research collaboration.Read moreRead less
New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and manageme ....New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and management that can reduce risk and improve patient survival.Read moreRead less
The effectiveness of pro-active telemarketing of a smoking cessation telephone counselling service. Despite the availability of services, such as telephone support lines to help people quit, only a small number of smokers seek help. One solution is to pro-actively contact and offer support with quitting to smokers in the community. This study will involve pro-actively contacting households by telephone and offering intensive, personalised telephone counselling to smokers to support them in the q ....The effectiveness of pro-active telemarketing of a smoking cessation telephone counselling service. Despite the availability of services, such as telephone support lines to help people quit, only a small number of smokers seek help. One solution is to pro-actively contact and offer support with quitting to smokers in the community. This study will involve pro-actively contacting households by telephone and offering intensive, personalised telephone counselling to smokers to support them in the quitting process. Such a service will provide treatment to smokers who might not otherwise seek assistance to quit, thereby greatly increasing the potential impact of quit smoking services at a community level.Read moreRead less
Fibre Optic Dosimeters for Medical and Environmental Applications. We will develop fibre optic dosimeters for environmental monitoring and radiation therapy. A novel approach using refractive index gradients will be used to capture scintillator light while rejecting noise. New knowledge will be gained of the mechanisms of radiation damage in scintillators and glasses. The small, flexible, accurate fibre optic dosimeters will be equivalent in absorbing characteristics to human tissue, making them ....Fibre Optic Dosimeters for Medical and Environmental Applications. We will develop fibre optic dosimeters for environmental monitoring and radiation therapy. A novel approach using refractive index gradients will be used to capture scintillator light while rejecting noise. New knowledge will be gained of the mechanisms of radiation damage in scintillators and glasses. The small, flexible, accurate fibre optic dosimeters will be equivalent in absorbing characteristics to human tissue, making them superior to all currently available dosimeters. Fibre optic dosimeters will enable new adaptive radiotherapy techniques and provide quality assurance of dose delivery in radiotherapy. Their multiplexing capability will lead to applications in monitoring of workplaces and aerospace environments.Read moreRead less
Intelligent Image Processing Techniques for Novel Biomarker Discovery. This project will make an impact on Australia's international research profile by seeking a solution to a worldwide challenging problem in biomarker discovery for the detection of diseases at an early stage which requires the incorporation of the skills and knowledge from biology, medicine, engineering, computer science, and information technology. The successful outcomes of this research will make an impact on Australia's e ....Intelligent Image Processing Techniques for Novel Biomarker Discovery. This project will make an impact on Australia's international research profile by seeking a solution to a worldwide challenging problem in biomarker discovery for the detection of diseases at an early stage which requires the incorporation of the skills and knowledge from biology, medicine, engineering, computer science, and information technology. The successful outcomes of this research will make an impact on Australia's engagement in using advanced image analysis and intelligent methods for the emerging research and development of targeted drug discovery. Read moreRead less
Evolutionary algorithms for problems in functional genomics data analysis. Skin cancer has a high incidence in the Australian population. Schizophrenia is a psychiatric disorder that affects a significant proportion of the population worldwide. Both illnesses have genetic roots and can be triggered by environmental factors. We will uncover genetic relationship to disease and their responses to environmental conditions using computational methods and mathematical algorithms that can aid in the de ....Evolutionary algorithms for problems in functional genomics data analysis. Skin cancer has a high incidence in the Australian population. Schizophrenia is a psychiatric disorder that affects a significant proportion of the population worldwide. Both illnesses have genetic roots and can be triggered by environmental factors. We will uncover genetic relationship to disease and their responses to environmental conditions using computational methods and mathematical algorithms that can aid in the determination of function, especially in disease states. Understanding the complex genetic interactions that trigger these illnesses would give great benefits in preventive health care, skin cancer and schizophrenia genetic basis, and may lay the ground for building new methods for "personalized medicine".
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100010
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the ....A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the nation's research priorities. It will enable: fundamental studies of cancer, neural diseases and immune disorders; the development of frontier technologies, such as smart nanomaterials, biosensors and targeted drug delivery; and applied research to help plants and soils adapt to climate variability, and to increase sustainable use of water.Read moreRead less